San Diego Padres vs San Francisco Giants Prediction 3/31/26 MLB Picks Today

The San Francisco Giants and the San Diego Padres meet Tuesday in MLB action from Petco Park. We will look at this from a betting perspective and determine the best bets for this game. Here’s a San Francisco Giants vs. San Diego Padres prediction.

Starting Pitching Matchup

The San Francisco Giants will send out Logan Webb for the start here and Webb is 0-1 with a 10.80 ERA and 7 strikeouts this season. In his last five starts against the Padres, Webb is 1-3 with a 4.60 ERA and 23 strikeouts. The San Diego Padres will send out German Marquez here and Marquez was 3-16 with a 6.70 ERA and 83 strikeouts last season. In his last five starts against the Giants, Marquez is 0-4 with a 7.30 ERA and 18 strikeouts. 

San Francisco Giants Recap

The San Francisco Giants come into this game looking to add on to their 3-2 win over the Padres from Monday’s opener to improve to 1-3 this season. After this series, the Giants will head home for a series against the New York Mets.

Giants Nab First W Of Season

Going into Monday’s opener, Rafael Devers, Luis Arraez and Heliot Ramos each have 3 hits with Devers and Ramos each logging a double while Matt Chapman has an RBI and Jung Hoo Lee has a double. Willy Adames and Harrison Bader each have a base knock as well this season.

Why the San Francisco Giants will win

San Francisco Giants Player Prop Facts

San Diego Padres Recap

The San Diego Padres come into this game looking to bounce back from their loss at the hands of the Giants on Monday to sit at 1-3 this season. After this series, the San Diego Padres will head on the road for a series against the Boston Red Sox.

Padres Looking To Even Up Series

Entering Monday’s series opener, Xander Bogaerts has 3 hits with a double and an RBI while Ramon Laureano has 5 hits with a double, a home run and two RBIs. Jackson Merrill and Manny Machado each have a pair of hits with a double and Jake Cronenworth has 3 hits as well this season. Fernando Tatis Jr. also has a pair of base hits and an RBI as well this season.

Why the San Diego Padres will win

San Diego Padres Player Prop Facts

Total Runs Facts

San Francisco Giants vs. San Diego Padres Prediction

I’m on the over here. I was on the under on Monday but I think the over is the way to go here. I didn’t love how Logan Webb looked against the Yankees in his opening start, and that was at home where Webb’s been far more effective his entire career, and now faces a Padres team that’s had his number over the years. On the other side, I don’t know how German Marquez nabbed another starting job at the MLB level, but I think that this is headed for a higher-scoring game so give me the over here.

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