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San Diego Padres vs St. Louis Cardinals 9/22/22 MLB Picks, Predictions, Odds

St. Louis Cardinals (87-63) vs. San Diego Padres (83-66)
September 22, 2022 4:10 pm EDT
The Line: San Diego Padres -142 / St. Louis Cardinals +120; Over/Under: +7.5
(Get latest betting odds)

The St. Louis Cardinals and San Diego Padres meet Thursday in MLB action at Petco Park. The St. Louis Cardinals look for a win after splitting their last 10 games. The San Diego Padres look to build on their 5-game winning streak.

The St. Louis Cardinals have scored 0 runs in their last 3 games and 3 or fewer runs in 5 of their last 7 games. The Cardinals have lost 5 of their last 6 games when scoring 3 or fewer runs. Paul Goldschmidt leads the Cardinals with 169 hits and 112 RBI, while Nolan Arenado and Tommy Edman have combined for 302 hits and 154 RBI. Jack Flaherty gets the ball, and he is 0-1 with a 5.09 ERA and 17 strikeouts this season. Flaherty is 1-0 with a 1.10 ERA and 16 strikeouts in his career against the Padres.


The San Diego Padres have scored 12 runs in their last 3 games and 3 or fewer runs in 6 of their last 9 games. The Padres have split their last 6 games when scoring 3 or fewer runs. Manny Machado leads the Padres with 157 hits and 93 RBI, while Jake Cronenworth and Jurickson Profar have combined for 254 hits and 133 RBI. Joe Musgrove gets the ball, and he is 10-7 with a 3.16 ERA and 165 strikeouts this season. Musgrove is 2-7 with a 5.53 ERA and 63 strikeouts in his career against the Cardinals.

The Cardinals are 14-3 in their last 17 during game 3 of a series and 36-15 in their last 51 overall. The Padres are 7-3 in their last 10 during game 3 of a series and 4-0 in their last 4 overall. The under is 4-0 in Cardinals last 4 overall. The under is 6-1 in Padres last 7 overall. The Cardinals are 0-6 in the last 6 meetings in San Diego and 6-1 in the last 7 meetings.

Jack Flaherty has been on the struggle bus for much of the season, but neither of these offenses are tearing the cover off the ball this week. Joe Musgrove has also been incredible this season, which includes a 3.33 ERA and .231 allowed batting average at home. Quick turnaround for both sides and quiet bats. I have to side with the under in this spot.

Randy Chambers's Free Pick: Under 7.5

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Randy Chambers

Randy has covered sports betting since 2014 and writes about everything from NFL to WNBA. Follow Randy Chambers on Twitter.

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