San Francisco Giants vs Arizona Diamondbacks Prediction 9/10/25 MLB Picks Today

The Arizona Diamondbacks and the San Francisco Giants meet Wednesday in MLB action from Oracle Park. We will look at this from a betting perspective and determine the best bets for this game. Here’s an Arizona Diamondbacks vs. San Francisco Giants prediction.

Starting Pitching Matchup

The Arizona Diamondbacks will send out Eduardo Rodriguez for the start here and Rodriguez is 7-8 with a 5.22 ERA and 124 strikeouts this season. In his career, Rodriguez is 1-1 with a 6.14 ERA and 22 strikeouts against the Giants. Carson Seymour will get the start for the Giants here and is 1-2 with a 4.25 ERA and 20 strikeouts this season. This will be Seymour’s first career start against the Diamondbacks.


Arizona Diamondbacks Recap

The Arizona Diamondbacks come into this game looking to rebound from a 5-3 loss at the hands of the Giants on Tuesday to sit at 72-74 on the year. After this series, the Diamondbacks will head on the road for a series against the Minnesota Twins.

Diamondbacks Lose Three In A Row

Corbin Carroll has 131 hits with 30 home runs, 74 RBIs, 16 triples and 29 doubles this season. Carroll also has a team-high 26 stolen bases and Geraldo Perdomo has 24 stolen bases as well as 17 home runs and 91 RBIs with a team-high 151 hits this season. Ketel Marte’s added 25 home runs and 64 RBIs as well on the year and Lourdes Gurriel has 124 hits with 24 doubles, 19 home runs and 80 RBIs.

Why the Arizona Diamondbacks will win

Arizona Diamondbacks Player Prop Facts

San Francisco Giants Recap

The San Francisco Giants come into this game looking to add on to their win over the Diamondbacks from Tuesday’s matchup to improve to 74-71 this season. After this series, the Giants will head home for a series against the Los Angeles Dodgers.

Giants Win 7 Of Last 9 Games

Jung Hoo Lee has 139 hits including a team-high 30 doubles along with 11 triples, 8 home runs and 51 RBIs with 10 stolen bases while Heliot Ramos has 146 hits with 23 doubles, 17 home runs and 61 RBIs. Wilmer Flores also 15 home runs and 67 RBIs while Tyler Fitzgerald has 9 stolen bases as well on the year. Matt Chapman also has 96 hits with 21 home runs and 56 RBIs along with 19 doubles and Willy Adames has 122 hits with 19 doubles, 28 home runs and 81 RBIs of his own this season. 

Why the San Francisco Giants will win

San Francisco Giants Player Prop Facts

Total Runs Facts

Arizona Diamondbacks vs. San Francisco Giants Prediction

I’m on the Giants in this one. I just can’t trust Eduardo Rodriguez in a starter’s capacity right now, and I think that the Giants can get to him here. Is Seymour a reliable option for the Giants? Not necessarily, but the Giants have the far more trustworthy bullpen when it gets to the later stages of this game and I think they get the job done here. Give me San Francisco here.

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