Mariners vs Padres Prediction 8/26/25 MLB Picks Today

The San Diego Padres and the Seattle Mariners meet Tuesday in MLB action from T-Mobile Park. We will look at this from a betting perspective and determine the best bets for this game. Here’s a Mariners vs Padres Prediction.

Starting Pitching Matchup

The San Diego Padres will send out Dylan Cease for the start and Cease is 6-11 with a 4.71 ERA and 178 strikeouts this season. This will be Cease’s second career start against the Mariners. Luis Castillo will get the nod for the Mariners here and is 8-7 with a 3.57 ERA and 127 strikeouts this season. In his last five starts against the Padres, Castillo is 3-1 with a 2.08 ERA and 35 strikeouts.

San Diego Padres Recap

The San Diego Padres come into this game looking to bounce back from a 9-6 loss at the hands of the Mariners to sit at 74-58 this season. After this series, the Padres will take to the road for an interleague series against the Minnesota Twins.

Padres Drop Back-To-Back Games

Manny Machado has 145 hits including a team-high 32 doubles, 21 home runs, 77 RBIs and 12 stolen bases while Fernando Tatis Jr. has 128 hits with 17 home runs and 52 RBIs along with 25 stolen bases of his own this season. Luis Arraez has added 144 hits with 27 doubles, 4 triples, 6 home runs and 47 RBIs while Jackson Merrill’s added 91 hits with 9 home runs and 51 RBIs as well. Xander Bogaerts also has 28 doubles and 19 stolen bases as well this season. Gavin Sheets also has 18 doubles, 17 home runs and 58 RBIs as well this season.

Why the San Diego Padres will win

San Diego Padres Player Prop Facts

Seattle Mariners Recap

The Seattle Mariners come into this game looking to add on to their series-opening win over the Padres from Monday’s matchup to sit at 71-61 on the year. After this set, the Mariners will travel to Cleveland for a series with the Guardians.

Mariners Win Back-To-Back Games

Jorge Polanco has 87 hits including 18 home runs and 54 RBIs while Cal Raleigh has 116 hits with 19 doubles, a team-high 47 home runs and 102 RBIs. Randy Arozarena has 114 hits with 25 doubles, 23 home runs, 59 RBIs and 24 stolen bases. Julio Rodriguez also has 138 hits with 24 doubles, 4 triples, 25 home runs, 71 RBIs and 23 stolen bases. Dylan Moore has 9 homers and 12 stolen bases as well this season. J.P Crawford has 122 hits with 19 doubles, 9 home runs and 44 RBIs.

Why the Seattle Mariners will win

Seattle Mariners Player Prop Facts

Total Runs Facts

Mariners vs Padres Prediction

I’m backing the Mariners in this one. I get the allure of the Padres here, but the problem has been Dylan Cease on the road for much of the season, as he still has an ERA well over five. He has yet to pick up a win on the road this year. I think Seattle’s bats keep it going here, so I’ll side with Seattle in this one.

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