The Arizona Diamondbacks and the St. Louis Cardinals meet Monday in MLB action from Busch Stadium. We will look at this from a betting perspective and determine the best bets for this game. Here’s an Arizona Diamondbacks vs. St. Louis Cardinals prediction.
Starting Pitching Matchup
The Arizona Diamondbacks will send out Merrill Kelly for the start here and Kelly is 5-6 with a 5.81 ERA and 42 strikeouts this season. The St. Louis Cardinals will start Andre Pallante and Pallante is 8-4 with a 3.76 ERA and 62 strikeouts this season.
Arizona Diamondbacks Recap
The Arizona Diamondbacks come into this game looking to shake off a 4-2 loss at the hands of Minnesota in their last game to sit at 39-38 this season. After this series, the Diamondbacks will head on the road for a series against the Tampa Bay Rays.
Diamondbacks Drop Back-To-Back Games
Corbin Carroll has 77 hits including 16 doubles, 9 triples, 13 home runs and 42 RBIs. Ketel Marte has 76 hits with 16 doubles, 12 home runs and 46 RBIs and Geraldo Perdomo has 61 hits, with 10 doubles, 3 triples, 4 home runs and 27 RBIs as well this season. Nolan Arenado also has 58 hits with 12 doubles, 8 home runs and 31 RBIs and Jose Fernandez has 42 hits with 3 home runs and 15 RBIs this season. Ildemaro Vargas also has 63 hits with 10 doubles, 2 triples, 7 home runs and 42 RBIs.
St. Louis Cardinals Recap
The St. Louis Cardinals come into this game looking to add on to their 12-10 win over Kansas City last time out to sit at 41-34 this season. After this series, the Cardinals will take on the Miami Marlins in a series at home.
Cardinals Snap Two-Game Skid
Jordan Walker leads the Cardinals with 85 hits, 16 doubles, 18 home runs and 58 RBIs while Alec Burleson has 84 hits with 19 doubles, 13 home runs and 55 RBIs. JJ Wetherholt has 74 hits with 12 home runs and 34 RBIs while Ivan Herrera has 73 hits with 13 doubles, 10 home runs and 38 RBIs. Nolan Gorman has 39 hits with 7 home runs and 26 RBIs this season. Masyn Winn’s added 62 hits with 11 doubles and 31 RBIs and Nathan Church has 47 hits with 5 home runs and 19 RBIs this season.
Arizona Diamondbacks @ St. Louis Cardinals Betting Trends: June 22, 2026
- Probable Starting Pitcher: Andre Pallante Record this season: 8-4 ERA: 3.76
- Home Record: 3-4
- Last 5 against Diamondbacks: 1-1
Why the St. Louis Cardinals will win
- The home team has won each of the last seven games between the Diamondbacks and Cardinals.
- The Diamondbacks have lost each of their last five road games against teams that held a winning record.
- The Diamondbacks have failed to cover the run line in nine of their last 10 night games against National League opponents following a home loss.
- The Cardinals have covered the run line in six of their last seven night games against NL West opponents that held a winning record.
- The Cardinals have won the first inning in each of their last three games.
- The Diamondbacks have trailed after 5 innings in each of their last 11 games as underdogs.
- The Diamondbacks have trailed after 3 innings in each of their last eight games as underdogs against NL Central opponents.
- Probable Starting Pitcher: Merrill Kelly Record this season: 5-6 ERA: 5.81
- Road Record: 3-3
- Last 5 against Cardinals: 2-0
Why the Arizona Diamondbacks will win
- The Diamondbacks have won six of their last seven games as underdogs against NL Central opponents following a home loss.
- The Cardinals have lost six of their last seven games as favorites following a road win.
- The Cardinals have failed to cover the run line in each of their last 12 games as favorites against NL West opponents following a win.
- The Diamondbacks have covered the run line in each of their last five games against the Cardinals.
- The Diamondbacks have led after 3 innings in four of their last five night games against the Cardinals.
- The Diamondbacks have won the first inning in three of their last four games against the Cardinals.
- The Diamondbacks have led after 5 innings in each of their last six night games against the Cardinals at Busch Stadium.
Total Runs Facts
- Each of the Cardinals’ last nine games against NL West opponents have gone UNDER the total runs line.
- Each of the Diamondbacks’ last eight road games after playing the previous day have gone UNDER the total runs line.
- There has been at least one run scored in the first inning in each of the Cardinals’ last four games.
- There has been at least one run scored in the first inning in five of the Diamondbacks’ last six games against NL Central opponents.
St. Louis Cardinals Player Prop Facts
- Alec Burleson has hit a home run in four of the Cardinals’ last eight night games.
- Lars Nootbaar has recorded at least one hit in each of his last 10 appearances in night games against teams that held a winning record.
- Ivan Herrera ranks 5th amongst qualified players for On Base Percentage (.405) this season.
Arizona Diamondbacks Player Prop Facts
- Nolan Arenado has hit a home run in three of his last four appearances against the Cardinals.
- Merrill Kelly has recorded four or more strikeouts in 18 of his last 19 appearances against NL Central opponents that held a winning record.
- Ildemaro Vargas has recorded at least one hit in 18 of his last 19 road appearances against opponents that held a winning record.
- Corbin Carroll is one of only two players to record 10+ Home Runs and 4+ Triples this season.
Matchup/League Facts
- The Cardinals rank 28th in the league for strikeouts this season (575).
- The Cardinals rank 4th in the league for strikeouts against this season (587).
- The Diamondbacks rank 1st in the league for triples this season (19).
- The Diamondbacks rank 30th in the league for strikeouts this season (536).
Arizona Diamondbacks vs. St. Louis Cardinals Prediction
I’m on the Cardinals in this one. The Cardinals have just been the better team in the month of June in my opinion, and Andre Pallante has quietly been one of St. Louis’ better options as a starter through the first half of the season so far. I think the Cardinals add another win to their docket here as Merrill Kelly has issues navigating the Cardinals and Arizona’s lack of run support comes back to bite Kelly here. Give me the Cards.