St. Louis Cardinals vs Cleveland Guardians Prediction 9-21-24 MLB Picks

In this article, we will formulate a St. Louis Cardinals vs Cleveland Guardians prediction for this MLB game on Saturday, September 21st at Busch Stadium in St. Louis, Missouri. Let’s take a look at the prediction for game two in the series.

St. Louis Cardinals Betting Preview

The St. Louis Cardinals are 77-77 this season and they have lost two games in a row. St. Louis lost game one in this series and only managed one run in the game. Prior to this series, the Cardinals won three out of four against the Pirates, lost all three against the Blue Jays, and won two out of three against the Reds. St. Louis is 3-5 in their last eight games and they are third in the NL Central. 

The St. Louis pitching staff has a 4.06 ERA, a 1.26 WHIP, and a .248 opponent batting average. The Cardinals’ offense has scored 627 runs with a .246 batting average and a .309 on-base percentage. Paul Goldschmidt is batting .245 with 21 home runs and 60 RBI’s for the Cardinals this season. 

Cleveland Guardians Betting Preview

The Cleveland Guardians are 90-65 this year and they have won three games in a row. Cleveland won game one in this series by a score of 5-1 on Friday night. Prior to this series, the Guardians won three out of four against the Twins, split four games with the Rays, and swept the White Sox. Cleveland is 6-1 in their last seven games and they are first in the AL Central. 

The Cleveland pitching staff has a 3.66 ERA, a 1.20 WHIP, and a .230 opponent batting average. The Guardians’ offense has scored 686 runs with a .238 batting average and a .309 on-base percentage. Jose Ramirez is batting .274 with 36 home runs and 109 RBI’s for the Guardians this season. 

Starting Pitchers

The projected starting pitcher for St. Louis is Miles Mikolas, who is 8-11 with a 5.49 ERA and a 1.29 WHIP over 160.2 innings pitched this year. Mikolas has allowed three earned runs or more in three of his last four starts. The projected starting pitcher for Cleveland is Matthew Boyd, who is 2-1 with a 2.52 ERA and a 1.07 WHIP over 35.2 innings pitched this season. Boyd has allowed two earned runs or fewer in five straight starts but has only gone 4.1 and 2.2 innings in his last two starts. 

Why the Guardians will beat the Cardinals

Total Runs Facts

St. Louis Cardinals Player Prop Facts

Cleveland Guardians Player Prop Facts

Matchup/League Facts

St. Louis Cardinals vs Cleveland Guardians Prediction 

Cleveland was able to get their third straight win on Friday night and they are rolling right now. The Guardians have a healthy lead in the AL Central and they are 42-37 on the road this year. St. Louis is 42-37 at home this season, but they have scored three runs or fewer in three of their last four games. I do like what I have seen from Boyd in his limited action this season for Cleveland, so I will back Cleveland to get a win against Mikolas, who is a below-average pitcher. 

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