St. Louis Cardinals vs Milwaukee Brewers Prediction 9/19/25 MLB Picks Today

The Milwaukee Brewers and the St. Louis Cardinals meet Thursday in MLB action from American Family Field. We will look at this from a betting perspective and determine the best bets for this game. Here’s a Milwaukee Brewers vs. St. Louis Cardinals prediction.

Starting Pitching Matchup

The Milwaukee Brewers will send out Jacob Misiorowski here and Misiorowski is 5-2 with a 4.35 ERA and 81 strikeouts this season. In his career, Misiorowski is 1-0 with a 3.60 ERA and 9 strikeouts against the Cardinals. Sonny Gray will get the start here and is 13-8 with a 4.43 ERA and 187 strikeouts this season. In his last five starts against the Brewers, Gray is 0-2 with a 5.93 ERA and 29 strikeouts.

Milwaukee Brewers Recap

The Milwaukee Brewers come into this game looking to add on to their 5-2 win over the Los Angeles Angels last time out to sit at 94-59 this season. After this series, the Brewers will head on the road for a series against the San Diego Padres.

Brewers Win Three Straight & 5 Of Last 6

Brice Turang has 156 hits with 18 home runs, 75 RBIs and 24 stolen bases while Jackson Chourio has 139 hits with a team-high 33 doubles, 18 stolen bases, 20 home runs and 75 RBIs and Sal Frelick has 145 hits as well as 3 triples, 10 home runs, 57 RBIs and 19 stolen bases so far this season. Christian Yelich also has 16 stolen bases with 28 homers and 96 RBIs while also adding 18 doubles. Yelich also has a team-high 157 strikeouts up to this point in the year. William Contreras has 17 homers and 74 RBIs as well this season. Joey Ortiz has chipped in 100 hits with 17 doubles, 7 home runs and 44 RBIs and Caleb Durbin also has 24 doubles with 11 homers and 49 RBIs. 

Why the Milwaukee Brewers will win

Milwaukee Brewers Player Prop Facts

St. Louis Cardinals Recap

The St. Louis Cardinals come into this game looking to rebound from their 6-2 loss at the hands of the Cincinnati Reds last time out to sit at 74-79 this season. After this series, the Cardinals will head on the road for a series against the San Francisco Giants.

Cardinals Drop 7 Of Their Last 9

Brendan Donovan has 124 hits along with 26 doubles, 10 home runs and 47 RBIs while Lars Nootbaar has 115 hits with 13 home runs, 47 RBIs, 23 doubles and 4 stolen bases. Nolan Arenado also has 87 hits with 16 doubles, 10 home runs and 45 RBIs of his own and Victor Scott II has 81 hits with 14 doubles, a triple, 37 RBIs and a team-high 33 stolen bases. Willson Contreras has also chipped in 126 hits with 31 doubles, 20 home runs and 80 RBIs of his own as well this season. Masyn Winn’s added 124 hits with 27 doubles, 9 home runs and 51 RBIs and Alec Burleson’s added 133 hits with 24 doubles, 18 home runs and 66 RBIs.

Why the St. Louis Cardinals will win

St. Louis Cardinals Player Prop Facts

Total Runs Facts

Milwaukee Brewers vs. St. Louis Cardinals Prediction

I’m on the Brewers here. I get the case to be made for a home dog in some spots, but the Brewers are the only team fighting for anything here and the recent form of both teams shows that. Sonny Gray’s been better at home this season, but I don’t feel like backing him with how well Milwaukee’s been playing overall and I think Jacob Misiorowski can match him here. Give me the Brew Crew.

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