The San Francisco Giants and the St. Louis Cardinals meet Tuesday in MLB action from Busch Stadium. We will look at this from a betting perspective and determine the best bets for this game. Here’s a San Francisco Giants vs. St. Louis Cardinals prediction.
Starting Pitching Matchup
The San Francisco Giants will send out Anthony Molina for the start here and Molina is 3-1 with a 5.24 ERA and 19 strikeouts this season. Matthew Liberatore will start for the Cardinals and is 5-14 with a 5.53 ERA and 146 strikeouts this season.
San Francisco Giants Recap
The San Francisco Giants come into this game looking to add on to their 10-3 win over St. Louis from Tuesday’s matchup to sit at 63-89 this season. After this series, the Giants will head on the road for a game against the Los Angeles Dodgers.
Giants Snap Four-Game Slide
Entering Tuesday, Willy Adames has 107 hits with 25 doubles, 21 home runs and 51 RBIs along with 139 strikeouts. Matt Chapman has 72 hits with 18 doubles, a triple, 7 home runs and 42 RBIs and Jung Hoo Lee has 144 hits with 29 doubles, 4 triples, 9 home runs and 55 RBIs. Rafael Devers also has 144 hits with 36 doubles, 37 home runs and 98 RBIs but also has 161 strikeouts this season.
St. Louis Cardinals Recap
The St. Louis Cardinals come into this game looking to rebound from their loss at the hands of the Giants on Tuesday to sit at 75-77 on the year. After this series, the Cardinals will take on Washington in a series at home.
Cardinals Have Two-Game Win Streak Halted
Going into Tuesday, Jordan Walker has 160 hits, 33 doubles, 28 home runs and 100 RBIs while Alec Burleson has 162 hits with 36 doubles, 22 home runs and 110 RBIs. JJ Wetherholt has 122 hits with 17 home runs and 48 RBIs while Ivan Herrera has 138 hits with 25 doubles, 16 home runs and 64 RBIs. Masyn Winn’s added 106 hits with 20 doubles and 54 RBIs and Nathan Church has 100 hits with 10 home runs and 50 RBIs this season.
San Francisco Giants @ St. Louis Cardinals Betting Trends: September 16, 2026
- Probable Starting Pitcher: Matthew Liberatore Record this season: 5-14 ERA: 5.53
- Home Record: 3-6
- Last 5 against Giants: 0-1
Why the St. Louis Cardinals will win
- The Giants have lost each of their last 10 games following a road win.
- The Cardinals have won seven of their last eight day games against the Giants following a home loss.
- The Cardinals have covered the run line in each of their last seven games following a home loss.
- The Giants have failed to cover the run line in each of their last four day games following a road win.
- The Cardinals have led after 5 innings in 10 of their last 11 day games against the Giants at Busch Stadium.
- The Cardinals have led after 3 innings in nine of their last 11 day games against the Giants at Busch Stadium.
- Probable Starting Pitcher: Anthony Molina Record this season: 3-1 ERA: 5.24
- Road Record: 2-0
- Last 5 against Cardinals: 0-0
Why the San Francisco Giants will win
- The Giants have won each of their last six games as underdogs against the Cardinals following a win.
- The Cardinals have lost each of their last six Wednesday games as favorites against NL West opponents.
- The underdogs have covered the run line in each of the last 14 games between the Giants and Cardinals.
- The Cardinals have failed to cover the run line in 12 of their last 13 games as home favorites against NL opponents.
- The Cardinals have trailed after 3 innings in three of their last four day games.
- The Cardinals have lost the first inning in five of their last six games against opponents that held a losing record.
- The Cardinals have trailed after 5 innings in each of their last three home day games.
Total Runs Facts
- Each of the Cardinals’ last five day games against NL West opponents have gone OVER the total runs line.
- Five of the Giants’ last six games have gone OVER the total runs line.
- There has been at least one run scored in the first inning in eight of the Cardinals’ last nine day games against NL opponents.
- There has been at least one run scored in the first inning in 14 of the Giants’ last 16 games.
St. Louis Cardinals Player Prop Facts
- Alec Burleson has hit a home run in two of the Cardinals’ last three home games against NL West opponents.
- Matthew Liberatore has recorded six or more strikeouts in each of his last three appearances in day games.
- Masyn Winn has recorded at least one hit in each of his last 10 appearances in day games against NL West teams that held a losing record.
- Alec Burleson ranks T7th in the league in Hits (163) this season.
San Francisco Giants Player Prop Facts
- Osleivis Basabe has hit a home run in four of his last eight road appearances against NL opponents.
- Anthony Molina has recorded a win in three of his last four appearances.
- Anthony Molina has recorded four or more strikeouts in each of his last three appearances.
- Bryce Eldridge has recorded at least one hit in 14 of his last 15 appearances against NL opponents that held a losing record.
Matchup/League Facts
- The Cardinals rank 27th in the league for slugging percentage this season (.384).
- The Cardinals rank 4th in the league for home runs allowed this season (151).
- The Giants rank 30th in the league for walks this season (425).
- The Giants rank 1st in the league for home runs allowed this season (144).
San Francisco Giants vs. St. Louis Cardinals Prediction
I’m on the Cardinals here. I get the case to be made for either side in this game, but the thing is that the Cardinals are in must-win mode after their horrid showing on Tuesday, and I think they bounce back here even though Liberatore hasn’t been a profitable option this season. I haven’t been able to trust the Giants to produce consistent offense at the best of times this season and I look for St. Louis to take care of business at home here. Give me the Cards.