Cardinals vs Giants Prediction 9/5/25 MLB Picks Today

The San Francisco Giants and the St. Louis Cardinals meet Friday in MLB action from Busch Stadium. We will look at this from a betting perspective and determine the best bets for this game. Here’s a Cardinals vs Giants Prediction.

Starting Pitching Matchup

The San Francisco Giants will send out Carson Seymour for the start here and Seymour is 0-2 with a 4.74 ERA and 18 strikeouts this season. This will be Seymour’s first career start against the Cardinals. The St. Louis Cardinals will send out Michael McGreevy for the start here and is 6-2 with a 4.17 ERA and 40 strikeouts this season. This will be McGreevy’s second career start against the Giants.

San Francisco Giants Recap

The San Francisco Giants come into this game looking to build on their 10-8 win over the Colorado Rockies last time out to sit at 70-71 on the year. After this series, the Giants will head home for a series against the Arizona Diamondbacks.

Giants Win 4 Straight and 9 Of Last 10

Jung Hoo Lee has 129 hits including a team-high 30 doubles along with 10 triples, 7 home runs and 48 RBIs with 10 stolen bases while Heliot Ramos has 143 hits with 23 doubles, 16 home runs and 59 RBIs. Wilmer Flores also 15 home runs and 67 RBIs while Tyler Fitzgerald has 9 stolen bases as well on the year. Matt Chapman also has 89 hits with 20 home runs and 64 RBIs along with 17 doubles and Willy Adames has 118 hits with 18 doubles, 26 home runs and 76 RBIs of his own this season. 

Why the San Francisco Giants will win

San Francisco Giants Player Prop Facts

St. Louis Cardinals Recap

The St. Louis Cardinals come into this game looking to add on to their 5-1 win over the Athletics last time out to sit at 70-71 on the year. After this series, the Cardinals will head on the road for a series against the Seattle Mariners.

Cardinals Win Back-To-Back Games

Brendan Donovan has a team-high 118 hits along with 25 doubles, 9 home runs and 45 RBIs while Lars Nootbaar has 106 hits with 13 home runs, 44 RBIs, 22 doubles and 4 stolen bases. Nolan Arenado also has 85 hits with 15 doubles, 10 home runs and 43 RBIs of his own and Victor Scott II has 79 hits with 14 doubles, a triple, 35 RBIs and a team-high 31 stolen bases. Willson Contreras has also chipped in 120 hits with 30 doubles, 20 home runs and 78 RBIs of his own as well this season. Masyn Winn’s added 122 hits with 27 doubles, 9 home runs and 51 RBIs and Alec Burleson’s added 123 hits with 21 doubles, 16 home runs and 60 RBIs.

Why the St. Louis Cardinals will win

St. Louis Cardinals Player Prop Facts

Total Runs Facts

Cardinals vs Giants Prediction

I’m on the Giants in this one. I get the case to be made for the Cardinals at home, but the Giants are just in better form right now and are surprisingly solid against right-handed pitching as of late over this run they’ve been on. The Cardinals continue to be so hit or miss offensively, and I just can’t trust them in a spot like this. Give me the Giants here.

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