Tigers vs Guardians Prediction 9/16/25 MLB Picks Today

The Detroit Tigers and Cleveland Guardians meet on Tuesday in MLB action from Comerica Park. Here’s a Tigers vs Guardians prediction. We will look at this from a betting perspective and determine the best Tigers vs Guardians pick. 

Can Tigers Build off Last Game?

Heading into Sunday’s game against the Miami Marlins, the Tigers had lost three games in a row. On Sunday, the Tigers scored only two runs total, but the pitching didn’t give up a run, and that was enough to pick up the victory. Spencer Torkelson had quite the game, finishing with one hit, one run, and two walks. Keider Montero was on the mound, and he went five innings giving up three hits and zero earned runs. 

The Tigers are averaging 4.86 runs while their pitching is giving up 4.22 runs per game. The offense is ranked 8th while the pitching is 13th. At times the pitching has been inconsistent, and they really need the pitching to be better. Riley Greene has hit 34 home runs and driven in 108 RBIs. Getting the start for the Tigers will be Casey Mize and he sits with a 14-5 record and an ERA of 3.83. Against the New York Yankees in his last start he went six innings giving up four hits and two runs. 

Why the Tigers Will Beat the Guardians 

Guardians Are on Fire

The Guardians are on fire heading into this game, and they have won four games in a row. To make the playoffs, this is really a series they need to find success in. In the last game against the Chicago White Sox, the Guardians scored three runs, and that was enough for the one run victory. Bo Naylor was the only offense for the Guardians, but he’s all they needed hitting a home run and driving in three RBIs. 

The Guardians are averaging 3.89 runs while their pitching is giving up 4.1 runs per game. The offense is ranked 28th while the pitching is ranked 9th. They overall have a negative run differential of -0.21 which is 19th. Joey Cantillo is getting the start for the Guardians and he sits with a 5-3 record and an ERA of 3.36. Against the Kansas City Royals he went eight innings giving up four hits and zero runs. Over his last four starts he has given up only three runs total. 

Why the Guardians Will Beat the Tigers

Tigers vs Guardians Prediction

The Guardians are the hotter team, and they are going to have no issue getting the job done in this game. Cantillo is on the mound for the Tigers and he’s going to dominate the Tigers bats which have been a bit inconsistent. Casey Mize has been good also, but even the two runs he ave up in the last game, isn’t going to end up being enough. The Guardians are going to score only three or four runs, but with as dominant as Cantillo will be, that is going to be enough. Back the Guardians on the money line.  

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