Tigers vs White Sox Prediction 4/6/25 MLB Picks Today

The Chicago White Sox and the Detroit Tigers meet Sunday in MLB action from Comerica Park. We will look at this from a betting perspective and determine the best bets for this game. Here’s a Chicago White Sox vs. Detroit Tigers prediction.

Starting Pitching Matchup

Martin Perez will get the start for the White Sox and is 1-0 with a 0.00 ERA and 9 strikeouts this season. In his last five starts against the Tigers, Perez is 0-0 with a 2.81 ERA and 24 strikeouts. Jackson Jobe will get the start for the Tigers here and is 0-0 with a 6.75 ERA and 3 strikeouts this season. This will be Jobe’s first career start against the White Sox.

Chicago White Sox Recap

The Chicago White Sox come into this game looking to avoid the sweep after falling short in Saturday’s matchup by a final score of 7-2 to drop to 2-7 on the year. After this series, the White Sox will head on the road for a series against the Cleveland Guardians.

White Sox Drop 4th Game In A Row

Andrew Benintendi leads the White Sox with 9 hits including 2 home runs, 6 RBIs and a .310 batting average while Miguel Vargas, Korey Lee and Andrew Vaughn each have a pair of doubles while Nick Maton has a pair of home runs as well this season. Brooks Baldwin has 5 RBIs while Vaughn has 4 RBIs.

Why the Chicago White Sox will win

Chicago White Sox Player Prop Facts

Detroit Tigers Recap

The Detroit Tigers come into this game looking to complete the sweep after ending up with the win on Saturday to improve to 4-4 on the year. After this game, the Tigers will welcome the New York Yankees to town for a series.

Tigers Win Back-To-Back Series

Riley Greene has a team-high 13 hits including 4 doubles, 3 home runs and 5 RBIs along with 11 strikeouts while Kerry Carpenter has 3 home runs and a team-high 8 RBIs as well on the year. Spencer Torkelson’s added 10 hits with 3 doubles, 2 home runs and 4 RBIs but also has a team-high 12 strikeouts so far this season. Trey Sweeney also has 8 hits with a double, a triple and a home run and 5 RBIs.

Why the Detroit Tigers will win

Detroit Tigers Player Prop Facts

Total Runs Facts

Chicago White Sox vs. Detroit Tigers Prediction

I’m on the White Sox +1.5 here. I get the case to be made for the Tigers at home, but I have a hard time trusting the Tigers at the best of times against left-handed pitching, but Perez has been solid for some time now and he also has solid career numbers against the Tigers in some of his recent starts with a sub-three ERA in his last five starts against Detroit. Jackson Jobe is a solid prospect, but I feel like this price with Jobe is rushing it a bit, as he wasn’t stellar in his debut and while the White Sox may be a good lineup to get your feet wet against and to gain some reps against, I think this is the best spot of the entire series for the White Sox to at least keep it close if not end up winning the game outright. Give me Chicago +1.5 here.

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