Twins vs Guardians Prediction 5/19/25 MLB Picks Today

In this article we will formulate a Twins vs Guardians prediction for this MLB game on Monday, May 19th at Target Field in Minneapolis, Minnesota. Let’s take a look at the prediction for this MLB matchup. 

Minnesota Twins Betting Preview

The Minnesota Twins are 26-21 this season after they won two out of three against Milwaukee by scores of 3-0, 7-0, and 2-5. In their game three loss, Minnesota cut the deficit to 4-2 in the seventh inning, but couldn’t get any closer in the loss. The Twins recorded six hits in the game and they were led by Lee and Lewis, who both had one RBI in the loss. Minnesota started Matthews, who allowed five hits and four earned runs over 3.0 innings for the loss, while Alcala allowed one earned run in the eighth. 

Prior to that series, the Twins swept the Orioles in three games and swept the Giants in three games. Minnesota has won 13 of their last 14 games and they are currently second in the AL Central standings. The Minnesota pitching staff has a 3.20 ERA with a 1.14 WHIP and a .228 opponent batting average, while their offense has scored 194 runs with a .242 batting average and a .310 on base percentage this season. Byron Buxton (IL) has led Minnesota with 10 home runs and 27 RBIs, while Trevor Larnach has added seven home runs and 23 RBIs this year. The projected starting pitcher for Minnesota is Bailey Ober, who is 4-1 with a 3.72 ERA and a 1.37 WHIP over 48.1 innings pitched this season. 

Cleveland Guardians Betting Preview

The Cleveland Guardians are 25-21 this year after they lost all three games against Cincinnati by scores of 4-5, 1-4, and 1-3. In their game three loss, Cleveland had plenty of baserunners, but only managed one run in the seventh inning for the loss. The Guardians recorded nine hits and they committed one error in the game, while they were led by Santana, who had the lone RBI in the game. Cleveland started Ortiz, who allowed six hits and two earned runs over 5.0 innings for the loss, while Gaddis allowed two hits and one earned run in the sixth. 

Prior to that series, the Guardians won two out of three against the Brewers, but dropped two out of three against the Phillies before that. Cleveland has lost four games in a row and they are currently third in the AL Central standings. The Cleveland pitching staff has a 4.14 ERA with a 1.41 WHIP and a .260 opponent batting average, while the offense has scored 182 runs with a .233 batting average and a .307 on base percentage this season. Kyle Manzardo has led Cleveland with 10 home runs and 25 RBIs, while Jose Ramirez has added nine home runs and 23 RBIs this year. The projected starting pitcher for Cleveland is Logan Allen, who is 2-2 with a 3.70 ERA and a 1.52 WHIP over 41.1 innings pitched this year. 

Why the Twins will beat the Guardians

Total Runs Facts

Minnesota Twins Player Prop Facts

Cleveland Guardians Player Prop Facts

Matchup/League Facts

Twins vs Guardians Prediction 

Minnesota finally had their winning streak snapped on Sunday afternoon, but they are still the hottest team in baseball over the last two weeks. The Twins are 15-6 at home this season, while the Guardians are 11-13 on the road. Cleveland has dropped four games in a row and they are starting Allen, who has been wildly inconsistent this year. Minnesota is going with Ober, who has allowed one earned run in four of his last five starts. Take Minnesota at home here. 

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