Twins vs Yankees Prediction 9/16/25 MLB Picks Today

The New York Yankees and Minnesota Twins meet Tuesday in MLB action at Target Field. Here’s a Twins vs Yankees Prediction. This article will include a Twins vs Yankees Pick.

New York Yankees Betting Preview

The New York Yankees are 83-67 on the year and play the Orioles, White Sox, and Orioles next. The New York Yankees are batting .248 on the season, have a .329 OBP, and a .452 slugging percentage. The New York Yankees pitching staff has a 4.02 ERA and a 1.27 WHIP. Aaron Judge leads the New York Yankees with 163 hits and 102 RBI, while Cody Bellinger and Paul Goldschmidt have combined for 276 hits and 136 RBI.


Cam Schlittler gets the ball for the New York Yankees, and he is 3-3 with a 3.05 ERA and 63 strikeouts this season. This will be Schlittler’s second career game against the Minnesota Twins.

Minnesota Twins Betting Preview

The Minnesota Twins are 66-84 on the year and play the Guardians, Rangers, and Phillies next. The Minnesota Twins are batting .240 on the season, have a .313 OBP, and a .400 slugging percentage. The Minnesota Twins pitching staff has a 4.58 ERA and a 1.33 WHIP. Byron Buxton leads the Minnesota Twins with 120 hits and 76 RBI while Trevor Larnach and Brooks Lee have combined for 227 hits and 118 RBI.

Zebby Matthews gets the ball for the Minnesota Twins, and he is 4-5 with a 5.06 ERA and 80 strikeouts this season. This will be Matthews’ second career game against the New York Yankees.

New York Yankees @ Minnesota Twins Betting Trends: September 16, 2025

 

Why the Minnesota Twins will win

 

Why the New York Yankees will win

Total Runs Facts

Minnesota Twins Player Prop Facts

New York Yankees Player Prop Facts

Matchup/League Facts

Twins vs Yankees Prediction

The Twins just don’t string wins together, and Matthews isn’t a pitcher I’m backing against this Yankees lineup. Matthews has an ERA over 5 on the season along with a 1.46 WHIP, and he’s allowed 41 hits and 18 earned runs in his last 36 innings. Schlittler has been solid for a rookie overall, and he has a 1.99 ERA and .195 allowed batting average in 22.2 road innings. I trust the Yankees more in this spot. Give me the Yanks.

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