Washington Nationals vs. San Diego Padres Prediction 05-24-2023 MLB Picks

Chris RuffoloMay 24, 2023
Washington Nationals vs. San Diego Padres Prediction 05-24-2023 MLB Picks player photo
Credit: USA Today Sports

The San Diego Padres and the Washington Nationals meet in MLB action from Nationals Park on Wednesday. Let’s dive into the odds, starting pitching matchup, history and make a prediction for this game.


San Diego is listed as a -165 road favorite while Washington is a +140 home underdog. The total for this game is set at 9.5 runs.

Starting Pitching Matchup

Ryan Weathers will start for the Padres and is 1-2 with a 3.42 ERA and 14 strikeouts this season. Washington will start Trevor Williams will start here and is 1-2 with a 4.26 ERA and 32 strikeouts this season.

Matchup History

San Diego’s 7-4 win over Washington on Tuesday made it three straight wins for the Padres in this head-to-head matchup.


San Diego is 3-9 in their last 12 games overall and 1-5 in their last 6 road games while the under is 6-0 in their last 6 Wednesday games. Washington is 42-91 in their last 133 home games and 13-38 in their last 51 games against a team with a left-handed starter while the over is 6-1 in their last 7 games against a team with a losing record.


I’m on the over here. I think the Padres are slightly more reliable when it comes to the offensive side of things and the ability to put runs on the board, but Washington can hold their own and I’m not loving this starting pitching matchup of Ryan Weathers and Trevor Williams. Sure, both guys can go and both have had solid spots this season, but I’ve made a pretty penny fading both in past seasons and I’m going to bank on a high-scoring game here.

Chris Ruffolo's Free Pick:Over 9.5
Chris Ruffolo photograph

Chris joined the Sports Chat Place team in August 2016 and has a proven system that combines multiple analytical and situational statistics and trends to give out thousands of winning picks over the last three years with winning records across all of the top leagues, Follow Chris Ruffolo on Twitter @ruffthepickdawg