White Sox vs Athletics Prediction 4/16/25 MLB Picks Today

In this article, we will formulate a White Sox vs Athletics prediction for this MLB game on Wednesday, April 16, at Rate Field in Chicago, Illinois. Let’s take a look at the prediction for this MLB matchup.

Athletics Betting Preview

The Athletics (7-10, 5-3 Away) are playing better on the road than at home so far in the season. After losing the home series to the Padres and Mets, the Athletics opened the current one with a 12-3 victory over the White Sox, scoring a season-high 12 runs in the process. Tyler Soderstrom exploded for two homers and six RBI, while Jeffrey Springs got the win after allowing three runs on three hits with four strikeouts and three walks in 5.0 innings.

This year, the Athletics average 4.06 runs per game (17th in the MLB) on a .242/.309/.400 triple-slash. When it comes to pitching, the A’s staff has a 4.91 ERA (27th) and 1.53 WHIP (28th). Tyler Soderstrom leads the Athletics with a .328 batting average, eight home runs, and 17 RBI this season.

Osvaldo Bido will take the mound for the Athletics on Wednesday. The 29-year-old right-hander has a 1-1 record in three starts this season with a 3.00 ERA and 1.60 WHIP in 15.0 innings.

Chicago White Sox Betting Preview

The Chicago White Sox (4-12, 4-6 Home) won their first series of the season after defeating the Red Sox in two of three games. They were on an eight-game losing skid before that and were swept by the Guardians and Tigers. The White Sox lost Game 1 of the current series against the A’s, 12-3. Andrew Vaughn blasted a three-run homer in the first inning, but that was all from Chicago. Sean Burke took the loss after allowing five runs on six hits with two strikeouts and two walks in 3.1 innings.

This season, the White Sox average 3.33 runs per game (26th in the MLB) on a .201/.272/.300 slash line. Regarding pitching, the White Sox’s staff has a 3.55 ERA (9th) and 1.27 WHIP (17th). Andrew Vaughn leads the White Sox with a .123 batting average, two home runs, and eight RBI this season.

The projected starting pitcher for the Patriots is Jonathan Cannon, who is 0-2 in three starts this season, with a 5.79 ERA and 1.64 WHIP in 14.0 innings.

Total Runs Facts

• Eight of the Athletics’ last 10 games as favorites against the White Sox have gone UNDER the total runs line.
• Fourteen of the White Sox’s last 18 games against AL West opponents have gone UNDER the total runs line.
• The ‘Inning 1 UNDER 0.5 runs’ market has hit in seven of the Athletics’ last eight road games against American League opponents.
• The ‘Inning 1 UNDER 0.5 runs’ market has hit in eight of the White Sox’s last 10 night games.

Matchup/League Facts

• The White Sox rank 29th in the league for RBIs this season (51).
• The White Sox rank 29th in the league for batting average this season (.200).
• The Athletics rank 28th in the league for ERA this season (4.80).
• The Athletics rank 27th in the league for walks allowed this season (72).

White Sox vs Athletics Prediction

These teams have traded wins in the past few years, as each recorded five in the previous ten H2H duels. Osvaldo Bido is currently in better form than Cannon, but I am backing the White Sox to score two or three runs against him early on. Cannon, on the other hand, had a strong first start of the season and kept the Angels off the scoreboard but then surrendered nine runs in the next two starts. I expect both starters to have some trouble in the opening five innings. I don’t think they will combine for 15 runs as in Game 1, but I believe we will have at least eight. Back the Over.