White Sox vs Cardinals Prediction 6/17/25 MLB Picks Today

The St. Louis Cardinals and Chicago White Sox meet Tuesday in MLB action at Rate Field. Here’s a White Sox vs Cardinals Prediction. This article will include a White Sox vs Cardinals Pick.

St. Louis Cardinals Betting Preview

The St. Louis Cardinals are 37-35 on the year and play the Reds, Cubs, and Guardians next. The St. Louis Cardinals are batting .255 on the season, have a .326 OBP, and a .391 slugging percentage. The St. Louis Cardinals’ pitching staff has a 3.99 ERA and a 1.28 WHIP. Brendan Donovan leads the St. Louis Cardinals with 79 hits and 26 RBI, while Willson Contreras and Nolan Arenado have combined for 126 hits and 81 RBI.

Matthew Liberatore gets the ball for the St. Louis Cardinals, and he is 3-6 with a 4.17 ERA and 62 strikeouts this season. This will be Liberatore’s second career game against the Chicago White Sox.

Chicago White Sox Betting Preview

The Chicago White Sox are 23-49 on the year and play the Blue Jays, Diamondbacks, and Giants next. The Chicago White Sox are batting .222 on the season, have a .295 OBP, and a .343 slugging percentage. The Chicago White Sox pitching staff has a 4.13 ERA and a 1.40 WHIP. Miguel Vargas leads the Chicago White Sox with 61 hits and 31 RBI, while Lenyn Sosa and Chase Meidroth have combined for 105 hits and 26 RBI.

Shane Smith gets the ball for the St. Louis Cardinals, and he is 3-3 with a 2.37 ERA and 64 strikeouts this season. This will be Smith’s first career game against the St. Louis Cardinals.

Why the Chicago White Sox will win

• The Cardinals have lost each of their last four games as favorites.
• The White Sox have won eight of their last 10 games as home underdogs following a loss.
• The Cardinals have failed to cover the run line in each of their last seven games against American League opponents.
• The underdogs have covered the run line in each of the Cardinals’ last seven games.
• The Cardinals have lost the first inning in each of their last five night games against American League opponents.
• The Cardinals have trailed after 5 innings in each of their last seven games against American League opponents.
• The White Sox have led after 3 innings in eight of their last nine night games against NL Central opponents that held a winning record.

Why the St. Louis Cardinals will win

• The White Sox have lost each of their last 12 night games against National League opponents that held a winning record.
• The Cardinals have won seven of their last eight road games against AL Central opponents following a loss.
• The Cardinals have covered the run line in each of their last eight road games following a road loss.
• The White Sox have failed to cover the run line in each of their last four games as underdogs against NL Central opponents.
• The White Sox have trailed after 5 innings in seven of their last eight night games against National League opponents that held a winning record.
• The White Sox have trailed after 3 innings in each of their last four games against NL Central opponents.

Chicago White Sox Player Prop Facts

• Miguel Vargas has hit at least one home run in seven of his last nine appearances against NL Central opponents that held a winning record.
• Miguel Vargas has recorded a Double in each of the White Sox’s last three games against NL opponents.
• Miguel Vargas has recorded at least one RBI in eight of his last nine appearances against NL Central opponents that held a winning record.
• Miguel Vargas has scored at least one run in each of the White Sox’s last four games.
• Luis Robert has recorded at least one hit in each of his nine previous appearances in night games against NL Central teams that held a winning record.
• Luis Robert ranks T4th in the league in Steals (21) this season.

St. Louis Cardinals Player Prop Facts

• Willson Contreras has hit a home run in two of the Cardinals’ last three road games against AL Central opponents that held a losing record.
• Willson Contreras has recorded at least one RBI in each of the Cardinals’ last eight games against AL opponents.
• Brendan Donovan has scored at least one run in eight of his last nine appearances after not playing the previous day.
• Willson Contreras has recorded at least one hit in each of the Cardinals’ last 10 games as favorites.
• Lars Nootbaar has recorded a Double in four of the Cardinals’ last five night games against AL opponents that held a losing record.
• Victor Scott II ranks T8th in the league in Steals (19) this season.

White Sox vs Cardinals Prediction

The White Sox are a team I’ve faded a lot over the years, and I don’t have much interest in them this season. However, the Cardinals are riding an ugly losing streak. Liberatore has been hitable with a 4.17 ERA on the season. Liberatore has a 4.45 ERA and .271 allowed batting average in 32.1 road innings. While the White Sox have issues, obviously, Smith has been a bright spot with a 2.37 ERA and 1.17 WHIP. In 33 home innings, Smith has a 2.18 ERA and a .190 allowed batting average. I don’t do this often, but give me the White Sox because of the starting pitching edge and the Cardinals’ terrible form.