White Sox vs Orioles Prediction 9/15/25 MLB Picks Today

In this article we will formulate a White Sox vs Orioles prediction for this MLB game on Monday, September 15th at Rate Field in Chicago, Illinois. Let’s take a look at the prediction for this MLB matchup. 

Chicago White Sox Betting Preview

The Chicago White Sox are 57-93 this year after they lost all three games against Cleveland by scores of 0-4, 1-3, and 2-3. In their game three loss, Chicago tied the game at two in the fifth inning, but allowed the winning run in the seventh in the defeat. The White Sox recorded five hits in the game and they were led by Vargas and Meidroth, who both had one RBI in the loss. Chicago started Gomez, who allowed two hits and two earned runs over 5.0 innings, while Eisert picked up the loss in relief. 


Prior to that series, the White Sox won two out of three against the Rays and two out of three against the Tigers. Chicago has lost four of their last six games and they are last in the AL Central standings. The Chicago pitching staff has a 4.21 ERA with a 1.36 WHIP and a .247 opponent batting average, while the offense has scored 600 runs with a .234 batting average and a .303 on base percentage this season. Lenyn Sosa has led Chicago with 20 home runs and 68 RBIs, while Andrew Benintendi has added 19 home runs and 60 RBIs this year. The projected starting pitcher for Chicago is Sean Burke, who is 4-10 with a 4.35 ERA and a 1.47 WHIP over 122.0 innings pitched this year. 

Baltimore Orioles Betting Preview

The Baltimore Orioles are 69-80 this season after they lost all three against Toronto by scores of 1-6, 4-5, and 2-11. In their game three loss, Baltimore led 1-0 in the second, but only scored once in the last seven innings for the loss. The Orioles recorded seven hits in the game and they were led by Mayo and Cowser, who both had one RBI in the loss. Baltimore started Suarez, who allowed two hits and one earned run over 3.0 innings, while Wolfram picked up the loss in relief. 

Prior to that series, the Orioles won all three against the Pirates and two out of three against the Dodgers. Baltimore has split their last six games and they are last in the AL East standings. The Baltimore pitching staff has a 4.63 ERA with a 1.38 WHIP and a .261 opponent batting average, while their offense has scored 635 runs with a .239 batting average and a .306 on base percentage this season. Jackson Holliday has led Baltimore with 17 home runs and 55 RBIs, while Gunnar Henderson has added 16 home runs and 62 RBIs this year. The projected starting pitcher for Baltimore is Kyle Bradish, who is 0-1 with a 2.65 ERA and a 0.94 WHIP over 17.0 innings pitched this season. 

Why the White Sox will beat the Orioles

Total Runs Facts

Chicago White Sox Player Prop Facts

Baltimore Orioles Player Prop Facts

Matchup/League Facts

White Sox vs Orioles Prediction 

Both of these teams were swept over the weekend and will be looking to get back on the right track here. Chicago is 32-43 at home this season, while Baltimore is 33-42 on the road. Baltimore allowed 22 runs in their three games against Toronto and they are starting Bradish, who has allowed two earned runs or fewer in three straight outings. Chicago is going with Burke, who has allowed three earned runs or fewer in five straight. Both of these pitchers have been solid in recent outings, but we have seen Chicago play much better at home. Take the White Sox here. 

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