White Sox vs Twins Prediction 4/1/25 MLB Picks Today

The Minnesota Twins and the Chicago White Sox meet on Tuesday in MLB action from Guaranteed Rate Field. This will be the second installment in a three-game series this week. Here’s a White Sox vs Twins prediction. We will look at this from a betting perspective and determine the best White Sox vs Twins pick.

Minnesota Twins Betting Preview

Minnesota took on the Saint Louis Cardinals in their weekend opening set. The Twins took a 5-3 loss in the Thursday matchup, then fell again on Saturday, this time 5-1. In the Sunday finale, Minnesota gave up three runs in the second and five in the third on the way to a 9-2 blowout loss. Willi Castro put up two hits with a solo homer, and Byron Buxton had the other RBI. Starter Bailey Ober had a bad day, pitching 2.2 innings and eight earned runs.

On Monday, in the series opener versus the White Sox, the Twins coughed up seven runs in the first two innings on the way to a rough 9-0 blowout loss. Minnesota only had two hits themselves, one by Castro and one by Ryan Jeffers (two walks). Starting pitcher Chris Paddack had a horrible outing, giving up nine earned runs on six hits and four walks in 3.1 innings of work.

In the starting pitcher slot for Tuesday, the Twins will send out Simeon Woods Richardson. Over his regular-season career, Richardson is 5-5 with a 4.17 ERA in 28 starts. He’s managed to strike out 117 batters in 133.2 innings total. Richardson has a 5-6 career record in the regular season with a 4.33 ERA in 30 games (29 starts).

Chicago White Sox Betting Preview

Over on the White Sox’s side, they took on the Los Angeles Angels in their first series of the season. Chicago had a nice game in the Thursday opener, posting an 8-1 victory. The Sox couldn’t keep the bats going in game two, however, notching a 1-0 defeat to even things up. In the Sunday rubber match, Chicago held a 2-2 tie through a lengthy rain delay but couldn’t get anything going when play resumed. The result was a 3-2 defeat. Nick Maton posted a solo home run in the loss, and Matt Thaiss had two hits with an RBI and a walk.

In the Monday game against Minnesota, the Sox bagged eight hits in their shutout win. Michael Taylor (two runs, two RBI, two hits), Andrew Benintendi (three RBI), and Andrew Vaughn (three RBI) each had a homer. Starting pitcher Martin Perez came away with 6.0 clean frames, nine Ks, no hits, and no walks in a very nice outing.

Shane Smith will make the start for the White Sox on Tuesday. It’ll be Smith’s major-league debut. This spring, Smith posted a 1-1 record with a 3.38 ERA in four starts. He gave up five hits in 10.2 innings of work total. The White Sox will meet the Tigers after this series.

Why the Chicago White Sox will win

Why the Minnesota Twins will win

Total Runs Facts

White Sox vs Twins Prediction

I’m going to lean toward taking a stab on the Twins, but they’ve got to find a way to plate some runs. It’ll be interesting to see what Smith can do in his MLB debut on the other side, as well. As for Richardson, he notched a 1-2 record with a 4.11 ERA in five games (three starts) this spring. If he can eat up some of the early innings without too much damage, the Twins will be looking pretty good on defense.

On Monday, Minnesota fell behind quickly on a bad outing from starter Paddack. The good news is that the bullpen posted a strong effort behind him, with three different arms (including Castro, who had a busy afternoon) logging a combined 4.2 clean innings, two hits, one walk, and three strikeouts. The bad news is that the offense failed—yet again. If Minnesota doesn’t get something going here, it’s going to be a long and fruitless series. I’m probably staying away from this one, all things considered.

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