White Sox vs Twins Prediction 8/22/25 MLB Picks Today

The Minnesota Twins and Chicago White Sox meet Friday in MLB action at Rate Field. Here’s a White Sox vs Twins Prediction. This article will include a White Sox vs Twins Pick.

Minnesota Twins Betting Preview

The Minnesota Twins are 58-69 on the year and play the Blue Jays, Padres, and White Sox next. The Minnesota Twins are batting .237 on the season, have a .309 OBP, and a .395 slugging percentage. The Minnesota Twins pitching staff has a 4.25 ERA and a 1.28 WHIP. Byron Buxton leads the Minnesota Twins with 99 hits and 61 RBI, while Trevor Larnach and Brooks Lee have combined for 192 hits and 103 RBI.

Zebby Matthews gets the ball for the Minnesota Twins, and he is 3-4 with a 5.06 ERA and 63 strikeouts this season. This will be Matthews’ first career game against the Chicago White Sox.

Chicago White Sox Betting Preview

The Chicago White Sox are 45-82 on the year and play the Royals, Yankees, and Twins next. The Chicago White Sox are batting .231 on the season, have a .301 OBP, and a .370 slugging percentage. The Chicago White Sox pitching staff has a 4.18 ERA and a 1.37 WHIP. Lenyn Sosa leads the Chicago White Sox with 108 hits and 55 RBI while Miguel Vargas and Chase Meidroth have combined for 181 hits and 62 RBI.

Aaron Civale gets the ball for the Chicago White Sox, and he is 3-8 with a 4.88 ERA and 65 strikeouts this season. Civale is 1-4 with a 4.34 ERA and 61 strikeouts in his career against the Minnesota Twins.

Why the Chicago White Sox will win

Why the Minnesota Twins will win

Chicago White Sox Player Prop Facts

Minnesota Twins Player Prop Facts

White Sox vs Twins Prediction

I’m not running to the window to back either side, as the White Sox are possibly the worst franchise in MLB, while the Twins are one of the most disappointing teams this season. Matthews has a 5.06 ERA and 1.44 WHIP on the season, and he has a 5.46 ERA and .283 allowed batting average on the road. Civale has allowed 17 hits and 12 runs in his last 15.2 innings, and he has a 6.25 ERA and .258 allowed batting average at home. Two bad teams but two rough pitchers in terrible form. This could be an offensive shootout. I’ll grab the over if forced to pick.

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