Cavaliers vs Pacers Prediction 11/21/25 NBA Picks Today

The Indiana Pacers and Cleveland Cavaliers meet Friday in NBA action at the Rocket Arena. Here’s a Cavaliers vs Pacers Prediction. This article will include a Cavaliers vs Pacers Pick.

Indiana Pacers Betting Preview

The Indiana Pacers lost to the Pistons, beat the Hornets, and they play the Pistons next. The Pacers have lost 13 of their last 15 games.


The Indiana Pacers are averaging 108.7 points on 40.1 percent shooting and allowing 123.2 points on 48.4 percent shooting. Bennedict Mathurin is averaging 31 points and 7 rebounds, while Pascal Siakam is averaging 24.6 points and 7.1 rebounds. Andrew Nembhard is the third double-digit scorer, and Aaron Nesmith is grabbing 4.5 rebounds. The Indiana Pacers are shooting 30 percent from beyond the arc and 77.2 percent from the free-throw line. The Indiana Pacers are allowing 33 percent shooting from deep and are grabbing 46.8 rebounds per game.

Cleveland Cavaliers Betting Preview

The Cleveland Cavaliers beat the Bucks, lost to the Rockets, and they play the Clippers next. The Cavs have won 10 of their last 15 games.

The Cleveland Cavaliers are averaging 121.1 points on 45.3 percent shooting and allowing 117 points on 46.6 percent shooting. Donovan Mitchell is averaging 30.4 points and 5.4 assists, while Evan Mobley is averaging 19.2 points and 4.2 assists. De’Andre Hunter is the third double-digit scorer and Jarrett Allen is grabbing 7.8 rebounds. The Cleveland Cavaliers are shooting 34.7 percent from beyond the arc and 76.3 percent from the free throw line. The Cleveland Cavaliers are allowing 37.1 percent shooting from deep and are grabbing 43.8 rebounds per game.

Why the Cleveland Cavaliers will win

Why the Indiana Pacers will win

Total Points Facts

Cleveland Cavaliers Player Facts

Indiana Pacers Player Facts

Matchup/League Facts

Cavaliers vs Pacers Injury Report

The Cavs will be without Max Strus and Sam Merrill. Jaylon Tyson, Jarrett Allen, and Darius Garland are questionable.

The Pacers will be without Tyrese Haliburton, Obi Toppin, Kam Jones, Aaron Nesmith, Johnny Furphy, and Quenton Jackson.

Cavaliers vs Pacers Prediction

The Pacers have been fade material all season long and despite a win over the Hornets, I’m still not thrilled to get behind them. However, the Cavs have a lengthy list of injuries themselves and while they’re winning, they’re 5-11 ATS on the year. I’m not laying double-digit chalk with a team that’s not covering numbers. The underdog has covered 6 of the last 9 games between the Pacers and Cavs. The Cavs are 1-4 ATS in their last 5 games as a double-digit favorite. I want the boatload of points with the Pacers.

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