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San Francisco 49ers at Buffalo Bills- 10/16/16 NFL Pick, Odds, and Prediction

San Francisco 49ers (1-4) at Buffalo Bills (3-2)

NFL Football: Sunday, October 16, 2016 at 1:00 pm (New Era Field)

The Line: Buffalo Bills -7 -- Over/Under: 45.5 See the Latest Odds


The San Francisco 49ers look to snap out of their losing skid as they take to the road to face off against the surging Buffalo Bills.

The Niners are making a change at quarterback as they are switching to polarizing pivot Colin Kaepernick who has made more noise off the field than with his arms and legs of late but with Blain Gabbert struggling since the team’s opening week win against the Rams the teams felt a change was necessary. San Francisco is in tough this weekend though as they have to deal with a Bills team that is on a roll right now and is playing at home for the first time in two weeks and will certainly be fired up to play in front of their fans at the Ralph, and with Kaepernick getting the call, the defense without Navarro Bowman, and the offense as a whole just looking dismal I think this could be a long day for the Niners in Buffalo.

San Francisco 49ers at Buffalo Bills- 10/16/16 NFL Pick, Odds, and Prediction


The Bills meanwhile look to have hit another gear after taking down the Patriots two weeks ago at Gillette Stadium, and the Los Angeles Rams last weekend on the west coast, and now they return home to Orchard Park in front of Bills Mafia for a 1:00 PM start. The Bills still have issues on offense when it comes to the passing game as the loss of Sammy Watkins is huge, but luckily the Bills are riding Lesean McCoy right now and he has been absolutely brilliant, and against a hapless Niners defense I think he is in for another monstrous afternoon. Buffalo’s defense is also playing very well right now and if they can get Marcell Dareus and Jerry Hughes going early here I think the Bills can absolutely walk through this one in a game that figures to get out of hand early.

The Niners are 2-8-1 ATS in their last 11 against a team with a winning record, 0-4 ATS in their last four road games, and 1-5 in their last six following a loss while the Bills are 5-1 in their last six ATS on turf, 5-1 ATS in their last six home games, and 5-2 in their last seven ATS overall. This line will likely climb but Buffalo should have no issues covering here as they are hands down the play in this one.

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