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San Francisco 49ers at Arizona Cardinals - 10/1/17 NFL Pick, Odds, and Prediction

San Francisco 49ers (0-3) at Arizona Cardinals (1-2)

NFL Football: Sunday, October 1, 2017 at 4:05 pm (University of Phoenix Stadium)

The Line: Arizona Cardinals -6 -- Over/Under: 45 See the Latest Odds

TV: FOX

Down in Glendale at University of Phoenix Stadium on Sunday, we’ve got Week 4 NFL action between the San Francisco 49ers and the Arizona Cardinals. 

The 49ers are currently winless at 0-3 following defeats by Carolina 23-3, Seattle 12-9 and Los Angeles 41-39. In that Rams game, Niners QB Brian Hoyer posted 332 yards, two scores and one pick. Carlos Hyde led San Francisco with 25 carries for 84 yards and two touchdowns, while Pierre Garcon was the high man in receiving with seven catches for 142 yards. 

San Francisco 49ers at Arizona Cardinals - 10/1/17 NFL Pick, Odds, and Prediction

USA TODAY Sports

Through three games, Hoyer has 624 yards, two touchdowns and three picks, while Hyde is tops on the 49ers with 253 yards and two scores on 49 rush attempts. Garcon leads San Francisco in the receiving department with 25 targets, 16 receptions and 249 yards. 

As for the Cardinals, they’re sitting at 1-2 after losses to Detroit 35-23 and Dallas 28-17 sandwiched around an OT win over the Colts 16-13. In that Dallas game, Cardinals QB Carson Palmer finished 29-of-48 for 325 yards and two scores, most of the work going to veteran WR Larry Fitzgerald who had 13 receptions for 149 yards and a TD. Arizona put up just 49 rush yards on 21 carries in that one. 

On the season, Palmer has 925 yards, four touchdowns and four interceptions, while Fitzgerald is the top Arizona receiver with 34 targets, 22 receptions, 244 yards and a TD. Chris Johnson is the Cardinals’ top rusher with 23 attempts for 61 yards. 

The 49ers are 5-0 in their last five versus the NFC West and 4-1 ATS in their last five games overall. San Francisco is also 4-1 ATS in their last five versus the NFC and 6-2 ATS in their last eight games in Week 4. 

Meanwhile, the Cardinals are 2-5 ATS in their last seven games in October and 3-8 ATS in their last 11 versus the NFC. Arizona is also 1-4 ATS in their last five home games and 1-4 ATS versus a team with a losing record. 

The 49ers finally woke up on offense against the Rams, but blew it on defense after holding Seattle to just 12 points the week before. That last game shouldn’t have been that close, however, as LA made some major mistakes down the stretch. As for Arizona, they’ve looked utterly lost following the David Johnson injury, and in the wake of that catastrophe they’re averaging 2.8 rush yards as a team—that’s 64 attempts for 177 yards and one TD. That makes the Cards incredibly one-dimensional, and the Palmer/Fitzgerald combo can’t carry that load. Still, the Niners likely won’t offer much of a challenge, as they’ve got their own issues. I’ll take Arizona to cover in a sloppy football game.

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