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Arizona Cardinals at San Francisco 49ers - 10/7/18 NFL Pick, Odds, and Prediction

Arizona Cardinals (0-4) at San Francisco 49ers (1-3)

NFL Football: Sunday, October 7, 2018 at 4:25 pm (Levi's Stadium)

The Line: San Francisco 49ers -3 -- Over/Under: 41 See the Latest Odds

TV: FOX

The Arizona Cardinals and the San Francisco 49ers will match up in NFL activity on Sunday from Levi’s Stadium. 

Arizona comes into this one at 0-4 on the season so far. The Cardinals have lost to the Redskins 24-6, the Rams 34-0, the Bears 16-14 and the Seahawks 20-17 this season. 

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Arizona Cardinals at San Francisco 49ers - 10/7/18 NFL Pick, Odds, and Prediction

Kirby Lee-USA TODAY Sports

In the Seattle game, Cardinals QB Josh Rosen logged 180 yards with one TD, while David Johnson led the rush on 71 yards and a score. Ricky Seals-Jones was the top receiver for Arizona with 52 yards from two catches. 

Over on the Niners’ side, they’re sitting at 1-3 this season. San Francisco fell to the Vikings 24-16 to open up the year, then beat the Lions 30-27. In their last two games, the 49ers have fallen to the Chiefs 38-27 and the Chargers 29-27. 

In the Chargers game, San Fran QB CJ Beathard put up 298 yards with two TDs and two picks, and Matt Breida led the ground game on 39 yards from nine carries. George Kittle had a great game with six grabs for 125 yards and a receiving TD for the Niners. 

The Cardinals are 14-5 ATS in their last 19 road games versus a team with a losing home record and 5-2 ATS in their last seven following a straight-up loss. Arizona is 2-7 ATS in their last nine road games and 1-5 ATS in their last six in October. 

Meanwhile, the Niners are 4-1 ATS versus a team with a losing record and 7-2 ATS in their last nine in the NFC West. San Francisco is also 5-2 ATS in their last seven in Week 5 and 4-12 ATS in their last 16 home games. 

The Cardinals seem destined to play for draft position this year, but the good news is that after those two blowouts to start the season they’ve lost by just five combined points over their last pair of games against a pair of decent teams. 

There’s not much optimism surrounding the Niners this year either, but aside from the Chiefs game they’ve been within one score of their other two losses. There’s not a whole lot of intrigue in this one on either side, but it should be a good matchup. I’ll go 49ers.

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