MNF Picks: San Francisco 49ers vs Buffalo Bills 12/7/20 NFL Picks, Odds, Predictions

MNF Picks: San Francisco 49ers vs Buffalo Bills 12/7/20 NFL Picks, Odds, Predictions Photo by Mark J. Rebilas-USA TODAY Sports

Buffalo Bills (8-3) at San Francisco 49ers (5-6)

NFL Football: Monday, December 7, 2020 at 8:15 pm (State Farm Stadium)

The Line: San Francisco 49ers +2.5 -- Over/Under: 48 Click to Get Latest Betting Odds

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The San Francisco 49ers take on the Buffalo Bills and meet on Monday Night Football in week 13 NFL action at State Farm Stadium.

The Buffalo Bills look to stay hot after winning four of their last five games. The Buffalo Bills have won three of their last five road games. Josh Allen is completing 68.8 percent of his passes for 3,028 yards, 22 touchdowns and eight interceptions. Allen has two or more touchdown passes in eight of his last 11 games. Stefon Diggs and Cole Beasley have combined for 1,612 receiving yards and seven touchdowns while John Brown has 29 receptions. The Buffalo Bills ground game is averaging 104.4 yards per contest, and Devin Singletary leads the way with 483 yards and one touchdown. Defensively, Buffalo is allowing 25.6 points and 373.1 yards per game. Jordan Poyer leads the Buffalo Bills with 93 tackles, AJ Klein has five sacks and Tre'Davious White has two interceptions.

The San Francisco 49ers look for another win to get back to a .500 record. The San Francisco 49ers have lost four of their last five home games. Nick Mullens is completing 67.5 percent of his passes for 1,642 yards, six touchdowns and seven interceptions. Mullens and Jimmy Garoppolo have combined for 13 touchdown passes and 12 interceptions this season. George Kittle and Brandon Aiyuk have combined for 920 receiving yards and five touchdowns while Kendrick Bourne has 32 receptions. The San Francisco 49ers ground game is averaging 112.3 yards per contest, and Raheem Mostert leads the way with 346 yards and two touchdowns. Defensively, San Francisco is allowing 23.1 points and 315.2 yards per game. Fred Warner leads the San Francisco 49ers with 85 tackles, Kerry Hyder Jr. has 7.5 sacks and Jamar Taylor has two interceptions.

Get the Experts BEST BETS For Today's Games

The Bills are 9-4-2 ATS in their last 15 road games, 1-4 ATS vs. a team with a losing record and 0-3-1 ATS in their last 4 Monday games. The 49ers are 13-3 ATS in their last 16 Monday games, 1-4 ATS in their last 5 home games and 1-5 ATS in their last 6 games on grass. The over is 7-3-1 in Bills last 11 games overall. The under is 5-2 in 49ers last 7 games as an underdog. The favorite is 4-1 ATS in their last 5 meetings.

The Buffalo Bills continue to find themselves in close games and you're almost waiting for things to fall apart, but they continue to win and they're taking care of business in the games they're supposed to. The San Francisco 49ers had probably their best game yet last week in a road victory over the Rams, and the defense continues to show up, and it's only going to be more consistent with the return of Richard Sherman. With all that said, the Bills are almost being overlooked with this line, as they've been head and shoulders the better and more consistent team this season. I would need more points to even consider looking the 49ers way in this matchup. I'll gladly lay the small line with the Bills.

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Randy’s Pick Buffalo Bills -2.5

The pick in this article is the opinion of the writer, not a Sports Chat Place site consensus.

Mitch's Take...

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