NFL Saturday Picks: Arizona Cardinals vs San Francisco 49ers 12/26/20 NFL Picks, Odds, Predictions

NFL Saturday Picks: Arizona Cardinals vs San Francisco 49ers 12/26/20 NFL Picks, Odds, Predictions Photo by Mark J. Rebilas-USA TODAY Sports

San Francisco 49ers (5-9) at Arizona Cardinals (8-6)

NFL Football: Saturday, December 26, 2020 at 4:30 pm (State Farm Stadium)

The Line: Arizona Cardinals -3.5 -- Over/Under: 49 Click to Get Latest Betting Odds

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The Arizona Cardinals face off with the San Francisco 49ers Saturday in week 16 NFC West NFL action at State Farm Stadium in Phoenix.

The San Francisco 49ers need a win here to snap a three-game losing streak. The San Francisco 49ers have split their last six road games. Nick Mullens is completing 64.7 percent of his passes for 2,437 yards, 12 touchdowns and 12 interceptions. Mullens and Jimmy Garoppolo have combined for 19 touchdown passes and 17 interceptions this season. Brandon Aiyuk and Kendrick Bourne have combined for 1,308 receiving yards and seven touchdowns while George Kittle has 37 receptions. The San Francisco 49ers ground game is averaging 112.6 yards per contest, and Raheem Mostert leads the way with 521 yards and two touchdowns. Defensively, San Francisco is allowing 25.1 points and 314.3 yards per game. Fred Warner leads the San Francisco 49ers with 101 tackles, Kerry Hyder Jr. has 7.5 sacks and Jamar Taylor has two interceptions.

The Arizona Cardinals look for a third straight win to keep their playoff hopes alive. The Arizona Cardinals have split their last six home games. Kyler Murray is completing 67.8 percent of his passes for 3,637 yards, 26 touchdowns and 11 interceptions. Murray has seven touchdown passes in his last three games. DeAndre Hopkins and Christian Kirk have combined for 1,869 receiving yards and 12 touchdowns while Larry Fitzgerald has 48 receptions. The Arizona Cardinals ground game is averaging 147.8 yards per contest, and Kenyan Drake leads the way with 874 yards and nine touchdowns. Defensively, Arizona is allowing 23.5 points and 350 yards per game. Jordan Hicks leads the Arizona Cardinals with 107 tackles, Haason Reddick has 11 sacks and Patrick Peterson has three interceptions.

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The 49ers are 7-2 ATS in their last 9 Saturday games and 1-6 ATS in their last 7 games overall. The Cardinals are 4-1-1 ATS in their last 6 games in December and 2-5 ATS in their last 7 games overall. The under is 5-2 in 49ers last 7 games as an underdog. The under is 7-3 in Cardinals last 10 vs. NFC. The 49ers are 0-5-1 ATS in their last 6 meetings. The road team is 6-2-1 ATS in their last 9 meetings.

The San Francisco 49ers have shown improved offensive play with Mullens at quarterback, but they're still piling up the losses and have failed to cover six of their last seven games. The Arizona Cardinals need to keep winning if they want to lockup a playoff spot, and they've won their last two games by an average of 13 points. The Cardinals won the first meeting this season by four points, and they've won eight of the last 10 meetings against the 49ers overall. The Cardinals should roll in this contest.

See Who The Experts Picked To Win This One

Randy’s Pick Arizona Cardinals -3.5

The pick in this article is the opinion of the writer, not a Sports Chat Place site consensus.

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