San Francisco 49ers (2-2) vs. Arizona Cardinals (4-0)
October 10, 2021 4:25 pm EDT
The Line: Arizona Cardinals -5.5 / San Francisco 49ers +5.5; Over/Under: 50
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The Arizona Cardinals and San Francisco 49ers do battle late Sunday afternoon in a week 5 NFL NFC West showdown at State Farm Stadium in Glendale. The San Francisco 49ers need a win here to get a game above a .500 record. The Arizona Cardinals are riding their first 4-0 start since the 2012 NFL season.
The San Francisco 49ers have won three straight road games. Jimmy Garoppolo is completing 66.1 percent of his passes for 925 yards, five touchdowns and two interceptions. Deebo Samuel and George Kittle have combined for 717 receiving yards and three touchdowns while Kyle Juszczyk has 11 receptions. The San Francisco 49ers ground game is averaging 120.2 yards per contest, and Elijah Mitchell leads the way with 146 yards and one touchdown. Defensively, San Francisco is allowing 24.3 points and 316.7 yards per game. Fred Warner leads the San Francisco 49ers with 36 tackles, Nick Bosa has four sacks and Dre Greenlaw has one interception.
The Arizona Cardinals have split their last eight home games. Kyler Murray is completing 76.1 percent of his passes for 1,273 yards, nine touchdowns and four interceptions. AJ Green and Christian Kirk have combined for 492 receiving yards and four touchdowns while DeAndre Hopkins has 17 receptions. The Arizona Cardinals ground game is averaging 147.8 yards per contest, and Chase Edmonds leads the way with 255 yards on 43 carries. Defensively, Arizona is allowing 23.5 points and 350 yards per game. Isaiah Simmons leads the Arizona Cardinals with 23 tackles, Chandler Jones has five sacks and Byron Murphy Jr. has two interceptions.
The 49ers are 4-1 ATS in their last 5 vs. NFC West and 4-9 ATS in their last 13 games overall. The Cardinals are 1-5 ATS in their last 6 home games and 2-7 ATS in their last 9 games overall. The under is 5-2-1 in 49ers last 8 vs. NFC West. The under is 5-2 in Cardinals last 7 games overall. The 49ers are 1-5-1 ATS in their last 7 meetings.
The San Francisco 49ers have won twice this season on the road, but they’ve had a tough stretch of games lately, are banged up and the defense has shown signs of slipping, as they’re now ranked 22nd in scoring defense. The Arizona Cardinals finally get a home game, as three of their first four contests were on the road, and they’re firing on all cylinders offensively. The Cardinals are first in both total offense and scoring offense. The line isn’t cheap, but this feels like a rough spot for the 49ers. I’ll take the Cards by a touchdown.