San Francisco 49ers vs Indianapolis Colts 10/24/21 NFL Picks and Predictions

Indianapolis Colts (2-4) vs. San Francisco 49ers (2-3)
October 24, 2021 8:20 pm EDT
The Line: San Francisco 49ers -3.5 / Indianapolis Colts +3.5; Over/Under: 45
(Click here for latest betting odds)

The San Francisco 49ers and Indianapolis Colts meet in week 7 NFL Sunday Night Football (SNF) from Levi’s Stadium in Santa Clara, California.

The Indianapolis Colts come into this one looking to add onto their 31-3 win over the Houston Texans last time out. Carson Wentz has thrown for 1,545 yards, 9 touchdowns and an interception on 64.2% passing, while Jonathan Taylor’s rushed for a team-high 472 yards and 4 touchdowns. Michael Pittman Jr. leads the Colts in receiving with 31 catches for 403 yards on the year, while Taylor and Zach Pascal each have 200+ receiving yards as well. Another four Indianapolis pass-catchers have at least 100 receiving yards this season. On defense, Bobby Okereke has a team-high 51 total tackles while Darius Leonard has a team-high 2 interceptions and three Colts have a pair of sacks to lead the way in that department.

Winning Props Bets

The San Francisco 49ers come into this one rested after their bye week following a 17-10 loss to Arizona in their last game. Jimmy Garoppolo has thrown for 925 yards, 5 touchdowns and a pair of interceptions on 66.1% passing while Elijah Mitchell, Trey Sermon and Trey Lance all have 100+ rushing yards this season. Deebo Samuel leads San Fran’s receiving group with 31 grabs for 548 yards and 3 TDs while George Kittle has 19 catches for 227 yards and Kyle Juszczyk has 135 receiving yards this year. On defense, Fred Warner leads the 49ers with 45 total tackles while Nick Bosa has a team-high 5 sacks and Dee Ford has 3 sacks of his own this season.

Indianapolis is 7-2 ATS in their last 9 road games and 4-1 ATS in their last 5 games overall while the over is 4-1 in their last 5 games as a road underdog. San Francisco is 5-22-1 ATS in their last 28 games as a home favorite and 1-5 ATS in their last 6 home games while the under is 6-1 in their last 7 games following a loss.

Maybe I’m asking the obvious question, but why are the Niners so heavily favored here. They’re dealing with two banged up QBs, a mess at running back and are simply incapable of avoiding the injury bug. Sure, Carson Wentz is a turnover machine with ankles like a baby deer, but he’s the better option even though I never thought I’d hear myself say those words. I’m going with the Colts and the points in this one.

Chris Ruffolo's Free Pick:
Indianapolis +3.5
Free Bet Match Up To $1,001; Use code DAWGZRF

Chris Ruffolo

Chris joined the Sports Chat Place team in August 2016 and since then he's worked tirelessly to pick out winners across a wide range of sports from NBA,NHL,MLB and NFL and even into the college ranks of football and basketball as well. Chris has carried over his drive and determination from playing sports at a young age to crushing the competition on a daily basis here at Sports Chat Place!

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