New Orleans Saints vs Buffalo Bills 11/25/21 NFL Picks, Odds and Predictions

Buffalo Bills (6-4) vs. New Orleans Saints (5-5)
November 25, 2021 8:20 pm EDT
The Line: New Orleans Saints +6 / Buffalo Bills -6; Over/Under: +45.5
(Click here for latest betting odds)

The New Orleans Saints and Buffalo Bills square off Thanksgiving night in week 12 NFL action at Caesars Superdome in New Orleans. The Buffalo Bills look for a win after splitting their last six games. The New Orleans Saints look to snap a three-game losing streak.

The Buffalo Bills have won three of their last five road games. Josh Allen is completing 65.7 percent of his passes for 2,811 yards, 21 touchdowns and 8 interceptions. Stefon Diggs and Emmanuel Sanders have combined for 1,304 receiving yards and 10 touchdowns, while Cole Beasley has 57 receptions. The Buffalo Bills ground game is averaging 118.8 yards per contest, and Devin Singletary leads the way with 415 yards and 2 touchdowns. Defensively, Buffalo is allowing 17.6 points and 283.7 yards per game. Jordan Poyer leads the Buffalo Bills with 56 tackles, Greg Rousseau has 3 sacks and Micah Hyde has 3 interceptions.

The New Orleans Saints have split their last four home games. Trevor Siemian is completing 56.9 percent of his passes for 920 yards, 8 touchdowns and 2 interceptions. Deonte Harris and Marquez Callaway have combined for 790 receiving yards and 8 touchdowns, while Alvin Kamara has 32 receptions. The New Orleans Saints ground game is averaging 117.9 yards per contest, and Kamara leads the way with 530 yards and 3 touchdowns. Defensively, New Orleans is allowing 21.8 points and 342 yards per game. Demario Davis leads the New Orleans Saints with 66 tackles, Marcus Davenport has 5.5 sacks and PJ Williams has 3 interceptions.

The Bills are 7-3 ATS in their last 10 road games and 1-3-1 ATS in their last 5 games overall. The Saints are 5-2 ATS in their last 7 Thursday games and 5-2 ATS in their last 7 games in November. The over is 7-3 in Bills last 10 road games. The over is 4-0 in Saints last 4 games overall. The Bills are 0-5 ATS in their last 5 meetings.

The Buffalo Bills should win this game by a decent margin, but they also shouldn’t have gotten smoked by the Colts at home or lost to the Jaguars. The New Orleans Saints have their issues as well, and who would have thought Siemian would be a downgrade from Jameis Winston? With all that said, we’re getting a free touchdown with the home team on a short week. I also have lost a lot of confidence in the Bills, so nothing surprises me here. Give me the Saints.

Randy Chambers's Free Pick:
New Orleans Saints +6
Free Bet Match Up To $1,001; Use code DAWGZRF

Randy Chambers

Randy has covered sports betting since 2014 and writes about everything from NFL to WNBA.

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