Week 3: Arizona Cardinals vs Los Angeles Rams 9/25/22 NFL Picks, Predictions, Odds

Los Angeles Rams (1-1) vs. Arizona Cardinals (1-1)
September 25, 2022 4:25 pm EDT
The Line: Arizona Cardinals +4 / Los Angeles Rams -4; Over/Under: +51.5
(Click here for latest betting odds)

The Arizona Cardinals and Los Angeles Rams square off Sunday in a week 3 NFC West NFL division from State Farm Stadium.

The Los Angeles Rams will look to build on their first win of the season, coming in a 31-27 win over Atlanta last time out. Matthew Stafford has thrown for 512 yards, 4 touchdowns and 5 interceptions on 72.7% passing, while Darrell Henderson Jr. leads the Rams in rushing with 94 rushing yards as well. Cooper Kupp has a team-high 29 catches for 236 yards and 3 touchdowns this season. On defense, Ernest Jones has a team-high 19 total tackles, while Bobby Wagner has a pair of sacks.

The Arizona Cardinals will look to build on their come-from-behind 29-23 OT win over Las Vegas last time out for their first win of the season. Kyler Murray has thrown for 470 yards, 3 touchdowns and an interception on 63.9% passing while Darrel Williams leads the Cardinals with 59 rushing yards. Greg Dortch leads the Cardinals’ receiving group with 11 grabs for 118 yards while Marquise Brown has 111 receiving yards this season. On defense, Budda Baker and Jalen Thompson each have a team-high 19 total tackles with Thompson logging a team-high 16 solo tackles and J.J. Watt has a sack this season.  

Los Angeles is 0-4 ATS in their last 4 games overall and 1-4 ATS in their last 5 games following a win while the over is 6-1 in their last 7 games of September. Arizona is 0-6 ATS in their last 6 home games and 1-4 ATS in their last 5 games following a win while the over is 4-0 in their last 4 games following an ATS win.

I’m looking at the over here. I’m not going near the Rams after they took their foot off of the gas in a pathetic showing against the Falcons, while the Cardinals were lucky to get what they did against the Raiders last time out. Both teams have had their problems defensively and both are capable of putting points up, so give me the over in what should be a fairly open and entertaining game.

Chris Ruffolo's Free Pick:
Over 51.5
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