49ers vs Rams Prediction 11/9/25 NFL Picks Today

The Los Angeles Rams and San Francisco 49ers meet Sunday in NFL action at Levi’s Stadium. Here’s a 49ers vs Rams Prediction. This article will include a 49ers vs Rams Pick.

Los Angeles Rams Betting Preview

The Los Angeles Rams beat the Jaguars and Saints, and they play the Seahawks next. The Rams have won 3 straight games. Matthew Stafford is completing 67.2 percent of his passes for 2,147 yards, 21 touchdowns, and 2 interceptions. Puka Nacua and Davante Adams have combined for 1,202 receiving yards and 11 touchdowns, while Kyren Williams has 20 receptions.

The Los Angeles Rams ground game is averaging 111.9 yards per contest, and Kyren Williams leads the way with 586 yards and 3 touchdowns. Defensively, Los Angeles is allowing 15.9 points and 302.9 yards per game. Nate Landman leads the Los Angeles Rams with 72 tackles, Byron Young has 9 sacks and Kam Curl has 2 interceptions.

San Francisco 49ers Betting Preview

The San Francisco 49ers beat the Giants, lost to the Texans, and play the Cardinals next. The San Francisco 49ers have split their last 6 games. Mac Jones is completing 67.2 percent of his passes for 1,832 yards, 10 touchdowns, and 5 interceptions. Kendrick Bourne and Christian McCaffrey have combined for 1,089 receiving yards and 4 touchdowns, while Ricky Pearsall has 20 receptions.

The San Francisco 49ers ground game is averaging 97.1 yards per contest, and Christian McCaffrey leads the way with 596 yards and 4 touchdowns. Defensively, San Francisco is allowing 20.9 points and 332.6 yards per game. Dee Winters leads the San Francisco 49ers with 59 tackles, Bryce Huff has 4 sacks and Deommodore Lenoir has 1 interception.

Why the Los Angeles Rams will win

Total Points Facts

San Francisco 49ers Player Prop Facts

Los Angeles Rams Player Prop Facts

Matchup/League Facts

49ers vs Rams Prediction

The Rams are getting the benefit of the doubt because they’ve been the better, healthier team this season and Puka is expected to return. The 49ers have been hit or miss at times, and their offense continues to have issues finishing drives. However, these are two of the better coached teams in the league, and I usually want points where I can get them. Also, this is a divisional matchup where the underdog has covered 8 of the last 10 games. Six of those covers were outright wins for the underdog. Kyle Shanahan always has his team ready. I’ll grab the points with the 49ers at home.

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