Arizona Cardinals vs San Francisco 49ers Prediction 11/16/25 NFL Picks Today

The San Francisco 49ers and the Arizona Cardinals meet in week 11 NFL action from State Farm Stadium on Sunday. We will look at this from a betting perspective and determine the best bets for this game. Here’s a San Francisco 49ers vs. Arizona Cardinals prediction.

San Francisco 49ers Recap

The San Francisco 49ers come into this game looking to bounce back from a 42-26 loss at the hands of the Los Angeles Chargers last time out to sit at 6-4 this season. After this game, the 49ers will head home for a game against the Carolina Panthers.

49ers Alternate Wins & Losses In 8 Straight

Mac Jones has thrown for 2,151 yards, 13 touchdowns and 6 interceptions on 69.6% passing while Brock Purdy has thrown for 586 yards, 4 touchdowns and 4 interception on 65.8% passing. Christian McCaffrey has a team-high 626 rushing yards while also leading the 49ers in receiving with 69 grabs for 692 yards and 4 touchdowns. Ricky Pearsall has 327 receiving yards and 20 receptions while Kendrick Bourne has 482 receiving yards and Jauan Jennings has 324 receiving yards and 3 TDs. Three more 49ers have 100+ receiving yards as well on the year. On defense, Dee Winters has a team-high 67 total tackles. As a unit, San Francisco’s defense has combined for 12 sacks and an interception so far this season. 

Why the San Francisco 49ers will win

San Francisco 49ers Player Prop Facts

Arizona Cardinals Recap

The Arizona Cardinals come into this game looking to bounce back from a 44-22 loss at the hands of the Seattle Seahawks last time out to sit at 3-6 this season. After this game, Arizona will head home for a game against the Jacksonville Jaguars.

Cardinals Drop 6 Of Last 7

Kyler Murray has thrown for 962 yards, 6 touchdowns and 3 interceptions on 68.3% passing along with a team-high 173 rushing yards while Jacoby Brissett has 1,118 passing yards, 8 touchdowns and a pick on 68.3% passing. Emari Demercado also has 233 rushing yards while Trey McBride has 61 catches for 603 yards and 6 touchdowns and Marvin Harrison Jr. has 34 catches for 525 yards and 4 TDs. Another three Cardinals also have 100+ receiving yards as well this season. On defense, Akeem Davis-Gaither also has a team-high 64 total tackles while Josh Sweat has 8 sacks and Calais Campbell has 5 sacks. As a unit, Arizona’s defense has combined for 18 sacks and 6 interceptions so far this season.

Why the Arizona Cardinals will win

Arizona Cardinals Player Prop Facts

Total Points Facts

San Francisco 49ers vs. Arizona Cardinals Prediction

I’m on the 49ers here. Arizona admittedly has played in some close games this season, especially at home, but the thing here is that San Francisco’s just the better team and it feels like Arizona is starting to be resigned to their fate that there won’t be playoff football in the desert this season. San Francisco is inconsistent, but the Cardinals have been consistently frustrating to back and I think the 49ers get it done. Give me the 49ers.

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