Bills vs Browns Prediction 12/21/25 NFL Picks Today

In this article, we will formulate a Bills vs Browns Prediction for this NFL Week 13 game on Sunday, December 21st. Let’s take a look at the prediction for this NFL matchup.

Cleveland Browns Preview

The Cleveland Browns have a 3-11 record this season and are sitting fourth in the AFC North. They are 5-9 ATS, 7-7 in Over/Under and have a 2-5 home record and a 1-6 away record. The Browns are coming off a 3-31 away loss against the Chicago Bears and will face the Steelers and Bengals next.

Offensively, the Browns average 16.1 points per game, ranking 29th in the NFL, while defensively, they allow 23.7 points per game, which is 19th. Cleveland averages 264.3 total yards per game (171.9 passing and 92.4 rushing), while allowing 279.1 total yards per game (110.1 rushing and 169 passing).

Shedeur Sanders leads the Browns with 946 passing yards with 52.2% completed passes and 5 touchdowns. Quinshon Judkins leads the team in rushing yards with 805, while Harold Fannin has a team-high 66 receptions for 667 receiving yards, and 4 touchdowns. Defensively, Carson Schwesinger has a team-high 133 total tackles (59 of them solo), while Myles Garrett leads the team in sacks, with 21.5.

Buffalo Bills Preview

The Buffalo Bills have a 10-4 record this season and are sitting second in the AFC East. They are 7-7 ATS, 7-7 in Over/Under and have a 6-1 home record and a 4-3 away record. The Bills are coming off a 35-31 away win against the New England Patriots and will face the Eagles and Jets next.

Offensively, the Bills average 29.4 points per game, ranking 3rd in the NFL, while defensively, they allow 23.1 points per game, which is 16th. Buffalo averages 381.2 total yards per game (222.7 passing and 158.5 rushing), while allowing 312.6 total yards per game (143.1 rushing and 169.5 passing).

Josh Allen leads the Bills with 3276 passing yards with 70% completed passes and 25 touchdowns. James Cook leads the team in rushing yards with 1415, while Khalil Shakir has a team-high 62 receptions for 650 receiving yards, and four touchdowns. Defensively, Cole Bishop has a team-high 76 total tackles (46 of them solo), while Joey Bosa leads the team in sacks, with 5, while Cole Bishop, Christian Benford, Maxwell Hairston and A.J. Epenesa each have two interceptions.

Buffalo Bills @ Cleveland Browns Betting Trends: Week 16

 

Why the Cleveland Browns will win

Why the Buffalo Bills will win

Total Points Facts

Cleveland Browns Player Prop Facts

Buffalo Bills Player Prop Facts

Matchup/League Facts

Bills vs Browns Prediction

In this Bills vs Browns Prediction, the Bills are coming as -10-point road favorites. The Bills have been the better team this season, as they have 10 total wins as opposed to the Browns’ 3. They also have four road wins while the Browns have just two at home and are coming into this matchup in good form, with three consecutive wins, while on the other hand, the Browns are 1-6 in their last 7 games and 2-5 against the spread. The Bills have the third-best offense in the league and are going up against the Browns’ fourth-worst, so I expect them to get the job done easily on the road today. Take the Bills and lay the -10 on the road.

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