Bills vs Buccaneers Prediction 11/16/25 NFL Picks Today

In this article we will formulate a Bills vs Buccaneers prediction for this NFL game on Sunday, November 16th at Highmark Stadium in Orchard Park, New York. Let’s take a look at the prediction for this week 11 matchup.

Buffalo Bills Betting Preview

The Buffalo Bills are 6-3 this season after they lost to Miami by a score of 30-13 last week. Buffalo trailed 16-0 at halftime and allowed 14 more points in the second half for the ugly loss. The Bills out gained Miami by a total of 376-370, went 5-15 on third downs, and lost the turnover battle by a total of 3-2 in the game. Josh Allen went 28-40 for 306 yards, two touchdowns, and one interception, while James Cook rushed 13 times for 53 yards. Khalil Shakir led the receivers with seven catches for 58 yards in the loss. The Buffalo defense recorded zero sacks and six tackles for loss in the game. 

Prior to that game, Buffalo defeated the Chiefs by a score of 28-21 and the Panthers by a score of 40-9. The Bills have won two of their last three games and they are currently second in the AFC East standings. Buffalo has scored 27.6 points per game with 231.2 passing yards and 153.2 rushing yards per game, while they have allowed 21.9 points against per game this season. Josh Allen has thrown for 2,139 yards, 15 touchdowns, and five interceptions, while James Cook has 920 rushing yards and seven scores on 166 carries this year. 

Tampa Bay Buccaneers Betting Preview

The Tampa Bay Buccaneers are 6-3 this year after they lost to New England by a score of 28-23 in their last game. Tampa Bay trailed 14-10 at halftime and they were outscored 14-13 in the second half in the loss. The Buccaneers were out gained by a total of 435-371, went 5-13 on third downs, and won the turnover battle by a total of 1-0 in the game. Baker Mayfield went 28-43 for 273 yards and three touchdowns, while Sean Tucker rushed nine times for 53 yards, Emeka Egbuka led the receivers with six catches for 115 yards and one touchdown in the loss. The TB defense recorded one sack and three tackles for loss in the game. 

Prior to that game, Tampa Bay defeated the Saints by a score of 23-3, but lost to the Lions by a score of 24-9 before that. The Buccaneers have lost two of their last three games and they are currently first in the NFC South standings. Tampa Bay has scored 24.4 points per game with 228.6 passing yards and 99.8 rushing yards per game, while they have allowed 22.9 points against per game this season. Baker Mayfield has thrown for 2,192 yards, 16 touchdowns, and two interceptions, while Emeka Egbuka has 40 receptions for 677 yards and six scores this year. 

Why the Buffalo Bills will win

Why the Tampa Bay Buccaneers will win

Total Points Facts

Buffalo Bills Player Prop Facts

Tampa Bay Buccaneers Player Prop Facts

Matchup/League Facts

Bills vs Buccaneers Prediction 

Buffalo comes into this matchup trying to bounce back from an ugly game against Miami last week, but they have lost three of their last five games. The Bills did defeat Kansas City in their last home game, but their defense is questionable. Tampa Bay has dropped two of their last three games and they continue to deal with a ton of injuries at their skill positions. Despite their injuries, Tampa Bay has scored at least 23 points in four of their last five games and should find success through the air in this matchup. I think we will see plenty of scoring in this one and I like the over here.

David Racey is 63-35 (64%) in the NFL this season and he is currently #1 on the NFL Leaderboard. David went 6-3 in the NFL last week and continues to be red hot. Click here for his premium plays for this week!

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