Bills vs Patriots Prediction 10/4/26 NFL Picks Today

In this article we will formulate a Bills vs Patriots prediction for this NFL game on Sunday, October 4th at Highmark Stadium in Orchard Park, New York. Let’s take a look at the prediction for this week 4 matchup.

Buffalo Bills Betting Preview

The Buffalo Bills are 3-0 this season after they defeated the Chargers by a score of 24-16 last week. Buffalo was tied 10-10 at halftime, but they trailed 13-10 in the fourth, before scoring 14 points in the final quarter for the win. The Bills out gained LA by a total of 350-348, went 6-12 on third downs, and lost the turnover battle by a total of 5-1 in the game. Josh Allen threw for 204 yards and two interceptions, while DJ Moore caught six passes for 67 yards. James Cook III rushed 24 times for 154 yards and one touchdown in the win. 

Prior to that game, Buffalo defeated the Lions by a score of 41-31 and the Texans by a score of 36-31. The Bills have scored 33.7 points per game with 246.7 passing yards and 155.0 rushing yards per game, while they have allowed 26.0 points against per game this season. Josh Allen has thrown for 786 yards with five touchdowns and two interceptions, while James Cook has rushed for 346 yards and two scores this season. 

New England Patriots Betting Preview

The New England Patriots are 1-2 this year after they lost to the Jaguars by a score of 35-6 last week. New England trailed 14-3 at halftime and they allowed 21 points in the second half for the ugly loss. The Patriots out gained Jacksonville by a total of 317-315, went 4-12 on third downs, and lost the turnover battle by a total of 3-1 in the game. Drake Maye threw for 199 yards and two interceptions, while Mack Hollins caught six passes for 87 yards. TreVeyon Henderson rushed eight times for 23 yards in the game. 

Prior to that loss, New England defeated the Steelers by a score of 20-3, but lost to the Seahawks by a score of 13-10 before that. The Patriots have scored 12.0 points per game with 197.7 passing yards and 109.3 rushing yards per game, while they have allowed 17.0 points against per game this season. Drake Maye has thrown for 585 yards with one touchdown and six interceptions, while Mack Hollins has 12 receptions for 156 yards this year. 

Why the Buffalo Bills will win

Why the New England Patriots will win

Total Points Facts

Buffalo Bills Player Prop Facts

New England Patriots Player Prop Facts

Matchup/League Facts

Bills vs Patriots Prediction 

Buffalo comes into this matchup with an undefeated record to start the season, but they did turn the ball over five times last week. The Bills have had some defensive issues in the first few weeks, but their offense has been elite. New England is coming off of a bad loss to the Jaguars and Maye has looked awful under center. I think the Patriots offense will get going here, but I don’t trust Maye on the road to keep pace with the Bills. Take Buffalo to cover at home. 

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