Bills vs Saints Prediction 9/28/25 NFL Picks Today

The New Orleans Saints and the Buffalo Bills meet in week 4 NFL action from Highmark Stadium on Sunday. We will look at this from a betting perspective and determine the best bets for this game. Here’s a Bills vs Saints Prediction.

New Orleans Saints Recap

The New Orleans Saints come into this game looking to bounce back from their 44-13 loss at the hands of Seattle last time out to sit at 0-3 this season. After this game, New Orleans will head home for a game against the New York Giants.

Saints Looking For Huge Upset For First Win

Spencer Rattler has thrown for 639 yards, 4 touchdowns and an interception on 67.2% passing while Alvin Kamara has 186 rushing yards and a touchdown to lead the Saints on the ground. Juwan Johnson has a team-high 176 receiving yards with a touchdown on 19 receptions while Chris Olave has a team-high 23 catches for 165 yards and Rashid Shaheed’s added 127 receiving yards and a TD as well. On defense, Demario Davis has a team-high 31 total tackles while Carl Granderson leads New Orleans with 3.5 sacks. 

Why the New Orleans Saints will win

New Orleans Saints Player Prop Facts

Buffalo Bills Recap

The Buffalo Bills come into this one looking to add on to their 31-21 win over the Miami Dolphins last time out to sit at 3-0 this season. After this game, the Bills will take on the New England Patriots in an AFC East matchup at home.

Bills Looking To Remain Unbeaten

Josh Allen has thrown for 755 yards and 5 touchdowns on 69.7% passing while also rushing for 114 yards and 2 scores. James Cook has a team-high 284 rushing yards and 4 touchdowns while Keon Coleman has a team-high 14 catches for 158 yards and a touchdown. Dalton Kincaid has 13 catches for 151 yards while Khalil Shakir and Josh Palmer each have 100+ receiving yards as well for Buffalo this season. On defense, Christian Benford leads the Bills with 15 total tackles while the Bills’ defense as a whole has combined for 6 sacks and an interception so far this season.

Why the Buffalo Bills will win

Buffalo Bills Player Prop Facts

Total Points Facts

Bills vs Saints Prediction

I’m leaning towards New Orleans and the points here. We’re still early enough in the season that a road trip to Buffalo won’t affect a dome team as much as it would in December. While New Orleans got throttled by Seattle, they’ve been somewhat competitive early on, and Buffalo already didn’t cover as a double-digit favorite last week. A 31-17 win for the Bills, which is totally believable, still gets us to the pay window with New Orleans, so give me the Saints and the points here.

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