Cardinals vs Falcons Prediction 12/21/25 NFL Picks Today

In this article we will formulate a Cardinals vs Falcons prediction for this NFL game on Sunday, December 21st at State Farm Stadium in Glendale, Arizona. Let’s take a look at the prediction for this week 16 matchup.

Arizona Cardinals Betting Preview

The Arizona Cardinals are 3-11 this season after they lost to Houston by a score of 40-20 in their last game. Arizona trailed 17-0 after the first quarter and 23-7 at halftime, before losing the second half 17-13 in the lopsided losses. The Cardinals were out gained by a total of 399-307, went 5-12 on third downs, and lost the turnover battle by a total of 2-0 in the game. Jacoby Brissett went 27-40 for 249 yards, three touchdowns, and one interception, while Michael Carter rushed 14 times for 56 yards. Trey McBride led the receivers with 12 catches for 134 yards and two scores in the loss. 

Prior to that game, Arizona lost to the Rams by a score of 45-17 and the Buccaneers by a score of 20-17. The Cardinals have lost six games in a row and they are currently last in the NFC West standings. Arizona has scored 21.6 points per game with 238.4 passing yards and 95.0 rushing yards per game, while they have allowed 27.7 points against per game this season. Jacoby Brissett has thrown for 2,708 yards, 18 touchdowns, and six interceptions, while Trey McBride has 105 receptions for 1,071 yards and 10 scores this season. 

Atlanta Falcons Betting Preview

The Atlanta Falcons are 5-9 this year after they defeated Tampa Bay by a score of 29-28 in their last game. Atlanta led 14-13 at halftime, but they trailed 28-14 in the fourth quarter, before scoring 15 points in the last 10 minutes to escape with the close win. The Falcons out gained TB by a total of 476-338, went 5-11 on third downs, and tied the turnover battle at one in the game. Kirk Cousins went 30-44 for 373 yards and three touchdowns, while Bijan Robinson rushed 19 times for 93 yards and one score. Kyle Pitts Sr led the receivers with 11 catches for 166 yards and three touchdowns in the win. 

Prior to that game, Atlanta lost to the Seahawks by a score of 37-9 and the Jets by a score of 27-24. The Falcons have split their last four games and they are currently third in the NFC South standings. Atlanta has scored 20.1 points per game with 217.7 passing yards and 122.7 rushing yards per game, while they have allowed 24.4 points against per game this season. Kirk Cousins has thrown for 1,218 yards, six touchdowns, and three interceptions, while Bijan Robinson has 1,174 rushing yards and six scores on 234 carries this year. 

Why the Arizona Cardinals will win

Total Points Facts

Arizona Cardinals Player Prop Facts

Atlanta Falcons Player Prop Facts

Matchup/League Facts

Cardinals vs Falcons Prediction 

Atlanta comes into this matchup after an upset win over Tampa Bay last week, but they have allowed at least 27 points in four of their last five games. The Falcons have been decent on offense, as they rely on Cousins at quarterback. Arizona has lost six games in a row and they have allowed at least 40 points in three of their last five. The Cardinals have scored 20 points or fewer in three straight games, but I think their passing attack will have a big game here. I think Atlanta has the best player on the field with Bijan, but I don’t trust their defense and I think this game could go either way, so give me the points with Arizona. 

David Racey is 93-71 (57%) in the NFL this season and is one of the top NFL cappers on the NFL Leaderboard. David went 10-2 in the NFL last Sunday/Monday. Click here for his premium plays for this week!

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