Cardinals vs Seahawks Prediction 9/25/25 NFL Picks Today

In this article we will formulate a Cardinals vs Seahawks prediction for this NFL game on Thursday, September 25th at State Farm Stadium in Glendale, Arizona. Let’s take a look at the prediction for this week 4 matchup.

Arizona Cardinals Betting Preview

The Arizona Cardinals are 2-1 this season after they lost to San Francisco by a score of 16-15 last week. Arizona trailed 6-3 at halftime, but they led 15-13 late in the fourth, before losing on a field goal as time expired. The Cardinals were out gained by a total of 355-260, went 5-15 on third downs, and won the turnover battle by a total of 1-0 in the game. Kyler Murray went 22-35 for 159 yards and one touchdown, while Trey Benson rushed 10 times for 42 yards. Marvin Harrison Jr. caught three passes for 44 yards to lead the receivers. The Arizona defense recorded one sack and three tackles for loss in the game.

Arizona started the season with a 20-13 win over New Orleans and a 27-22 win over Carolina in their first two games. The Cardinals are averaging 20.7 points per game with 165.0 passing yards and 111.3 rushing yards per game, while they are allowing 17.0 points against per game this season. Kyler Murray has completed 67.4% of his passes for 542 yards, four touchdowns, and one interception, while Trey McBride has caught 17 passes for 182 yards and one score. Trey Benson is the leading rusher for the Cardinals with 125 yards on 21 carries this season. 

Seattle Seahawks Betting Preview

The Seattle Seahawks are 2-1 this year after they defeated New Orleans by a score of 44-13 in their last game. Seattle led 21-0 after the first quarter and 38-6 at the half, before cruising to the easy victory. The Seahawks out gained NO by a total of 320-284, went 3-9 on third downs, and tied the turnover battle at one in the game. Sam Darnold went 14-18 for 218 yards and two touchdowns, while Kenneth Walker III carried the ball 16 times for 38 yards and two scores. Jaxon Smith-Njigba led the receivers with five catches for 96 yards and one touchdown in the game. The Seattle defense recorded two sacks and four tackles for loss in the win. 

Seattle opened the season with a 17-13 loss to San Francisco, but did win their second game by a score of 31-17 over Pittsburgh. The Seahawks are averaging 29.3 points per game with 219.0 passing yards and 96.0 rushing yards per game, while they are allowing 15.7 points against per game this season. Sam Darnold has completed 70.3% of his passes for 663 yards, four touchdowns, and two interceptions, while Jaxon Smith-Njigba has caught 22 passes for 323 yards and one score. Kenneth Walker III has led the rushing attack with 163 yards and three touchdowns on 39 carries this year. 

Why the Cardinals will beat the Seahawks

Total Points Facts

Arizona Cardinals Player Prop Facts

Seattle Seahawks Player Prop Facts

Matchup/League Facts

Cardinals vs Seahawks Prediction 

Both of these teams come into this contest with a 2-1 record on the year, so this is a big showdown in the NFC West. Seattle has scored 75 points in their last two games, but the Arizona defense has been very good this year. The Cardinals were good enough to win last week against the 49ers, but couldn’t finish the deal and only scored 13 offensive points. This should be a back and forth contest, but I think Arizona is the play. I don’t trust Darnold against a solid defensive unit and I think Arizona will do just enough to get the win. 

David Racey went 8-0 (100%) in the NFL last week and he is #1 on the NFL leaderboard. Click here for his premium plays for this week!

Exit mobile version