Chargers vs Colts Prediction 10/19/25 NFL Picks Today

In this article we will formulate a Chargers vs Colts prediction for this NFL game on Sunday, October 19th at SoFi Stadium in Inglewood, California. Let’s take a look at the prediction for this week 7 matchup.

Los Angeles Chargers Betting Preview

The Los Angeles Chargers are 4-2 this season after they defeated Miami by a score of 29-27 last week. Los Angeles trailed 13-9 at halftime and 27-26 with under a minute left, but they rallied and won on a field goal in the final seconds. The Chargers out gained Miami by a total of 403-341, went 6-15 on third downs, and won the turnover battle by a margin of 3-1 in the game. Justin Herbert went 29-38 for 264 yards and two touchdowns, while Kimani Vidal rushed 18 times for 124 yards in the game. Ladd McConkey led the receivers with seven receptions for 100 yards and one score in the win. The LA defense recorded two sacks and four tackles for loss in the game. 

Los Angeles also has wins against the Broncos, Raiders, and Chiefs, but they did lose to the Commanders and Giants. The Chargers have lost two of their last three games and they are currently tied for first in the AFC West standings. Los Angeles has scored 21.2 points per game with 240.0 passing yards and 120.7 rushing yards per game, while they have allowed 20.8 points against per game this season. Justin Herbert has thrown for 1,493 yards, 10 touchdowns, and four interceptions, while Keenan Allen has caught 33 passes for 316 yards and three scores this season. 

Indianapolis Colts Betting Preview

The Indianapolis Colts are 5-1 this year after they defeated Arizona by a score of 31-27 in their last game. Indianapolis led 14-10 at halftime, but they trailed 27-24 in the fourth quarter, before they scored the winning touchdown with about four minutes left. The Colts were out gained by a total of 400-355, went 4-8 on third downs, and tied the turnover battle at one in the game. Daniel Jones went 22-30 for 212 yards, two touchdowns, and one interception, while Jonathan Taylor rushed 21 times for 123 yards and one score. Tyler Warren led the receivers with six receptions for 63 yards and one touchdown in the win. The Indianapolis defense recorded two sacks and six tackles for loss in the game. 

Indianapolis also has wins against the Raiders, Titans, Broncos, and Dolphins, but they have one loss against the Rams so far this year. The Colts have won two games in a row and they are currently first in the AFC South standings. Indianapolis has scored 32.3 points per game with 245.0 passing yards and 131.8 rushing yards per game, while they have allowed 19.3 points against per game this season. Daniel Jones has thrown for 1,502 yards, eight touchdowns, and three interceptions, while Jonathan Taylor has rushed for 603 yards and seven scores this year. 

Why the Indianapolis Colts will win

Total Points Facts

Los Angeles Chargers Player Prop Facts

Indianapolis Colts Player Prop Facts

Matchup/League Facts

Chargers vs Colts Prediction 

Indianapolis rolls into this matchup with one of the best records in the NFL so far this year, but they will be on the road for this game. Daniel Jones is playing at a very high level right now and the Colts have scored at least 29 points in four of their last five games. The Chargers have lost two of their last three games, but did avoid a terrible loss to Miami in the final seconds last week. LA is dealing with some injuries right now and I don’t love what I have seen from them in the last three games. Take the Colts here. 

David Racey is 37-21 (64%) in the NFL this season and he is currently #1 on the NFL Leaderboard. Click here for his premium plays for this week!

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