Colts vs Titans Prediction 10/26/25 NFL Picks Today

The Tennessee Titans and Indianapolis Colts meet Sunday in NFL action at Lucas Oil Stadium. Here’s a Colts vs Titans Prediction. This article will include a Colts vs Titans Pick.

Tennessee Titans Betting Preview

The Tennessee Titans lost to the Raiders and Patriots, and they play the Chargers next. The Tennessee Titans have lost 6 of their last 7 games. Cam Ward is completing 57.6 percent of his passes for 1,356 yards, 4 touchdowns, and 5 interceptions. Calvin Ridley and Elic Ayomanor have combined for 545 receiving yards and 2 touchdowns, while Chig Okonkwo has 23 receptions.

The Tennessee Titans ground game is averaging 75.7 yards per contest, and Tony Pollard leads the way with 380 yards and 2 touchdowns. Defensively, Tennessee is allowing 27.4 points and 349.6 yards per game. Cedric Gray leads the Tennessee Titans with 70 tackles, Jeffery Simmons has 4.5 sacks and Cody Barton has 2 interceptions.

Indianapolis Colts Betting Preview

The Indianapolis Colts beat the Cardinals and Chargers, and they play the Steelers next. The Indianapolis Colts have won 3 straight games. Daniel Jones is completing 71 percent of his passes for 1,790 yards, 10 touchdowns, and 3 interceptions. Tyler Warren and Micheal Pittman Jr. have combined for 790 receiving yards and 8 touchdowns, while Alex Pierce has 16 receptions.

The Indianapolis Colts ground game is averaging 130.1 yards per contest, and Jonathan Taylor leads the way with 697 yards and 10 touchdowns. Defensively, Indianapolis is allowing 20 points and 345.7 yards per game. Nick Cross leads the Indianapolis Colts with 53 tackles, Tyquan Lewis has 3 sacks and Mekhi Blackmon has 2 interceptions.

Why the Indianapolis Colts will win

Why the Tennessee Titans will win

Total Points Facts

Indianapolis Colts Player Prop Facts

Tennessee Titans Player Prop Facts

Matchup/League Facts

Colts vs Titans Prediction

This is the first time the Colts have been a double-digit favorite since January 9, 2022, a game they outright lost to the Jaguars. It’s also the first time this season the Titans have been a double-digit underdog. With that said, I’m laying the points with the Colts. The Titans are awful on both sides of the ball and 2-5 ATS on the season. The Colts are not only winning, but they’re 5-2 ATS on the season.

This Colts’ offense will have a field day against a bad Titans defense, while the Colts run defense will force Ward to make plays through the air. He hasn’t proven he can do that yet on the NFL level. Big line, but expect a blowout win from the Colts at home.

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