Detroit Lions vs Buffalo Bills Prediction 12-15-24 NFL Picks

The Buffalo Bills and the Detroit Lions meet Sunday in NFL action from Ford Field. Here’s a Detroit Lions vs Buffalo Bills prediction. We will look at this from a betting perspective and determine the best Lions vs Bills pick.

Buffalo Bills Betting Preview

The Bills hit a 3-2 opening stretch this year, taking losses to the Ravens and Texans. Buffalo would go on a winning streak after that however, beating the Jets, Titans, Seahawks, Dolphins, Colts, Chiefs, and 49ers in the next seven games.


In their Week 14 game versus the Rams, the Bills gave up double-digit points in both the second and third quarters during a tough loss 44-42. Josh Allen threw for 342 yards and three scores while also leading the rush on 10 carries, 82 yards, and three more touchdowns.

Detroit Lions Betting Preview

Over on the Lions’ side, they’ve hit a stellar 12-1 run in their first 13 games. Detroit beat the Rams, Cardinals, Seahawks, Cowboys, Vikings, Titans, Packers, Texans, Jaguars, Colts, Bears, and Packers again in succession during that time.

In last Thursday’s matchup with the Packers, the Lions were outscored 24-17 in the second half but still managed to hold on for a 34-31 victory. QB Jared Goff finished with 283 yards, three scores, and a pick. Tops in receiving was Jameson Williams with five catches for 80 yards.

Total Points Facts

Detroit Lions Player Prop Facts

Buffalo Bills Player Prop Facts

Detroit Lions vs Buffalo Bills Prediction

I’ll probably go with the Bills here. We should have a pretty great matchup regardless, but a little bit of the luster has worn off thanks to Buffalo’s loss last weekend. In that one, the Bills gave up 457 total yards (320 passing) and 28 first downs. The offense didn’t really get moving until the fourth quarter (21 points) either. Still, the Bills have now scored 30 or more points in seven straight games.

As for the Lions, in their last game, they mustered 391 total yards (280 passing) and 27 first downs against a good Green Bay team in a pretty tight win. Detroit is now averaging 32.1 points per game and giving up 18.0 on the other side. That said, three of the Lions’ last five wins have been by just three points each (against Houston, Chicago, and Green Bay). Detroit will get the advantage of rest, preparation, and home field coming into this one so Buffalo is going to have to play some very good football in order to cover/win. I think the Bills can do it, though. Should be a fun one to check out.

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