Jaguars vs Chiefs Prediction 10/6/25 NFL Picks Today

The Kansas City Chiefs and the Jacksonville Jaguars meet in week 5 NFL action from EverBank Stadium on Monday. We will look at this from a betting perspective and determine the best bets for this game. Here’s a Jaguars vs Chiefs Prediction.

Kansas City Chiefs Recap

The Kansas City Chiefs come into this game looking to add on to their 37-20 win over Baltimore last time out to sit at 2-2 this season. After this game, the Chiefs will head home for a game against the Detroit Lions.


Chiefs Win Back-To-Back Games

Patrick Mahomes has thrown for 939 yards, 7 touchdowns and an interception on 61.3% passing while also leading the Chiefs in rushing with 130 yards and 2 touchdowns on the ground this season. Isiah Pacheco and Kareem Hunt each have 100+ rushing yards as well this season. Hollywood Brown leads Kansas City with 22 catches for 209 yards while Travis Kelce and Tyquan Thornton each have 182 receiving yards and a touchdown so far this season, with Thornton logging 3 TDs. JuJu Smith-Schuster also has 151 receiving yards and a touchdown for the Chiefs this season. On defense, Nick Bolton has a team-high 34 total tackles including 18 solo tackles while George Karlaftis has a team-high 3 sacks and Drue Tranquill has a pair of sacks so far this season for Kansas City. As a unit, Kansas City has combined for 9 sacks and 3 interceptions so far this season.

Why the Kansas City Chiefs will win

Kansas City Chiefs Player Prop Facts

Jacksonville Jaguars Recap

The Jacksonville Jaguars come into this game looking to build on their 26-21 win over San Francisco last time out to improve to 3-1 this season. After this game, the Jaguars will take on the Seattle Seahawks at home.

Jaguars Win Back-To-Back Games

Trevor Lawrence has thrown for 845 yards, 5 touchdowns and 4 interceptions on 58.3% passing while Travis Etienne Jr. leads the Jaguars on the ground with 394 rushing yards and 2 touchdowns. Brenton Strange leads Jacksonville with 19 catches for 182 yards while Brian Thomas Jr. has 164 receiving yards. Travis Hunter, Dyami Brown and Parker Washington all have 100+ receiving yards as well this season. On defense, Foyesade Oluokun has a team-high 30 total tackles while Devin Lloyd has a team-high 3 interceptions. Jacksonville’s defense as a whole has combined for 7 sacks and 9 interceptions so far this season.

Why the Jacksonville Jaguars will win

Jacksonville Jaguars Player Prop Facts

Total Points Facts

Jaguars vs Chiefs Prediction

I’m on the Chiefs here. I get the case to be made for the Jaguars at home, as they clearly have some swagger back in their step in a new system under Liam Coen. However, the Chiefs have come out in recent weeks and shown they’re far from dead. While the win over Baltimore could pose the threat of a letdown spot for KC here, I still think the Chiefs have more to prove and end up getting the win and cover on the road here.

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