Jaguars vs 49ers Prediction 9/28/25 NFL Picks Today

In this article, we will formulate a Jaguars vs 49ers Prediction for this NFL Week 4 game on Sunday, September 28th at the Levi’s Stadium. Let’s take a look at the prediction for this NFL matchup.

San Francisco 49ers Preview

The San Francisco 49ers have a 3-0 record this season and are sitting in 1st place of the NFC West. They are 2-1 ATS, 1-2 in Over/Under and have a 1-0 home record and 2-0 away record. The 49ers are coming off a 16-15 home win to Arizona Cardinals and are the Los Angeles Rams and Tampa Bay Buccaneers next.

Offensively, the 49ers average 19.7 points per game, which ranks 23rd in the NFL. Defensively, they allow 16.3 points per game, which is 3rd. San Francisco averages 361.0 total yards per game, with 89.7 rushing yards and 271.3 passing yards per game. They allow 265.7 total yards per game, with 89.7 rushing and 271.3 passing yards per game.

Mac Jones leads the 49ers with 563 passing yards and 66.3% completed passes. Christian McCaffrey leads the team in rushing yards, with 176, while Christian McCaffrey has a team-high 25 caught passes for 213 receiving yards, and has one touchdown. Defensively, Fred Warner has a team-high 30 total tackles, 16 of them solo. Nick Bosa leads the 49ers in sacks, with two.

Jacksonville Jaguars Preview

The Jacksonville Jaguars have a 2-1 record this season and are sitting on the 2nd place of the AFC South. They are 2-1 ATS, 1-2 in Over/Under and have a 0-1 away record and 2-0 home record. The Jaguars are coming off a 17-10 home win against the Houston Texans and are playing the Kansas City Chiefs and Seattle Seahawks next.

Offensively, the Jaguars average 23.3 points per game, which ranks 14th in the NFL. Defensively, they allow 17.0 points per game, which is 5th. Jacksonville averages 356.3 total yards per game, with 141.7 rushing yards and 223.7 passing yards per game. They allow 292.0 total yards per game, with 82.7 rushing and 209.3 passing yards per game.

Trevor Lawrence leads the Jaguars with 671 passing yards and 55.8% completed passes. Travis Etienne leads the team in rushing yards, with 270, while Brian Thomas has a team-high 13 caught passes for 137 receiving yards, and has one touchdown. Defensively, Foyesade Oluokun has a team-high 23 total tackles, 13 of them solo. Travon Walker leads the Jaguars in sacks, with two, while Andrew Wingard has one interception.

Jacksonville Jaguars @ San Francisco 49ers Betting Trends: Week 4

 

Why the San Francisco 49ers will win

Why the Jacksonville Jaguars will win

Total Points Facts

San Francisco 49ers Player Prop Facts

Jacksonville Jaguars Player Prop Facts

Matchup/League Facts

Jaguars vs 49ers Prediction

In their previous meeting in 2023, the 49ers won 34-3 on the road, and have won all of their five meetings against the Jaguars, including both meetings in San Fran. They are also a perfect 5-0 ATS and their last two meetings have gone under the total.

In this Jaguars vs 49ers Prediction, the 49ers are coming as -3-point home favorites, with the total set at 47 points. the 49ers have three straight wins after losing their season opener, while the Jaguars have lost both of their road games this season. The 49ers have the third-best defense in the NFL, and have never lost by the Jaguars. I don’t expect that to change soon, so take the San Francisco 49ers and lay the -3 points at home.

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