Chargers vs Broncos Prediction 9/21/25 NFL Picks Today

The Denver Broncos and the Los Angeles Chargers meet in week 3 NFL action from SoFi Stadium on Sunday. We will look at this from a betting perspective and determine the best bets for this game. Here’s a Chargers vs Broncos Prediction.

Denver Broncos Recap

The Denver Broncos come into this game looking to rebound from a 29-28 loss at the hands of the Indianapolis Colts last time out to slip to 1-1 on the year. After this game, the Broncos will head home for a game against the Cincinnati Bengals.

Broncos Looking For Rebound Showing

Bo Nix has thrown for 382 yards, 4 touchdowns and 3 interceptions on 67.1% passing while JK Dobbins has rushed for 139 yards and 2 touchdowns on the ground. Troy Franklin leads Denver’s receiving group with 12 catches for 133 yards and a touchdown. On defense, Talanoa Hufanga has a team-high 21 total tackles while Justin Strnad has a pair of sacks and as a whole, Denver’s defense has combined for 7 sacks so far this season.

Why the Denver Broncos will win

Denver Broncos Player Prop Facts

Los Angeles Chargers Recap

The Los Angeles Chargers come into this game looking to add on to their 20-9 win over the Las Vegas Raiders last time out to sit at 2-0 on the year. After this game, the Chargers will head on the road for a game against the New York Giants.

Chargers Looking To Remain Unbeaten

Justin Herbert has thrown for 560 yards and 5 touchdowns on 72.1% passing while Omarion Hampton leads Los Angeles in rushing with 72 rushing yards this season. Quentin Johnston has 150 receiving yards and 3 touchdowns to lead the Chargers’ group while Keenan Allen has 129 receiving yards and 2 touchdowns with 12 grabs and Ladd McConkey’s added 122 receiving yards as well. On defense, Daiyan Henley has a team-high 18 total tackles including 10 solo tackles and a pair of sacks while the Chargers’ defensive unit as a whole has combined for 5 sacks and 3 interceptions so far this season. 

Why the Los Angeles Chargers will win

Los Angeles Chargers Player Prop Facts

Total Points Facts

Chargers vs Broncos Prediction

I’m on the Chargers here. I just think that the Chargers have looked more impressive through two weeks. While I still think the Broncos have one of the best defensive units in the NFL, I don’t think there’s a huge drop-off when it comes to the Chargers. I think that Justin Herbert’s in really solid form right now to where I’m fine backing him in this spot at home. I’m concerned about a sophomore slump for Bo Nix, and I don’t know if this is a great spot for him either. Give me the Chargers here.

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