Rams vs Colts Prediction 9/28/25 NFL Picks Today

The Indianapolis Colts and the Los Angeles Rams meet Sunday in NFL action from SoFi Stadium. Here’s a Rams vs Colts prediction. We will look at this from a betting perspective and determine the best Rams vs Colts pick.

Indianapolis Colts Betting Preview

The Colts opened up the season with a matchup against the Miami Dolphins and things went pretty smoothly. Indy scored points in every quarter (double-digits in two of four) on the way to a 33-8 win. On offense the Colts accounted for 418 yards (262 passing) and 6.0 yards per play. In game two versus Denver, Indianapolis benefitted from a late penalty and ended up sneaking away with a 29-28 victory in the end. The Colts put up 473 yards (306 passing), 7.1 yards per play and 26 first downs this time, but also committed 11 penalties themselves.

In last weekend’s game versus the Tennessee Titans, the Colts were able to keep their run going. Indianapolis scored 17 points in the first quarter and 14 more in the third during a 41-20 victory. QB Daniel Jones was 18-of-25 for 228 yards and a touchdown, but Jonathan Taylor had the biggest day on offense with 17 carries for 102 yards and three scores. Michael Pittman was the leading receiver in the win with six grabs for 73 yards and a touchdown.

Los Angeles Rams Betting Preview

Over on the Rams’ side, they opened up their season with a matchup at home versus the Houston Texans. Los Angeles was down 9-7 at the break but eventually emerged victorious 14-9. The Rams’ offense accounted for 296 yards total, with 224 of those coming via the passing game. In their second matchup of the year versus the Tennessee Titans, Los Angeles held the opposition to a pair of second-half field goals in a 33-19 victory. The Rams got 439 yards of offense this time (290 passing) alongside 7.4 yards per play and 22 first downs.

Matched up against the reigning champion Philadelphia Eagles last weekend, the Rams were up 19-7 by the end of the first half. After getting outscored 26-7 from there however, Los Angeles had a 33-26 loss. QB Matthew Stafford was 19-of-33 for 196 yards, two touchdowns and an interception. Top team rusher Kyren Williams carried 20 times for 94 yards, and Puka Nacua caught 11 balls for 112 yards to pace the receivers.

Indianapolis Colts @ Los Angeles Rams Betting Trends: Week 4

 

Why the Los Angeles Rams will win

Why the Indianapolis Colts will win

Total Points Facts

Los Angeles Rams Player Prop Facts

Indianapolis Colts Player Prop Facts

Matchup/League Facts

Rams vs Colts Prediction

I’ll lean toward the Colts, but I’m probably avoiding this one. It could well be a trap for Indy as they put their unbeaten record on the line. That said, the Colts traveled well last weekend in the road win, generating 365 yards (228 passing), 6.9 yards per play and 22 first downs. Indianapolis wasn’t great on third downs (2-of-8), but the defense made up for it. The Colts allowed just 282 total yards (196 passing), 20 first downs and 4-of-14 on third-down conversions. It was Indianapolis’ highest points total of the year; they’ve now scored 29 or more in all three games.

As for Los Angeles, they started well against the reigning champion Eagles on Sunday but couldn’t close out the road win. The Rams defense wasn’t bad on 288 yards allowed (202 passing), 4.6 yards per play and 5-of-14 on third-down tries. That said, Philly also went 4-of-5 on fourth downs which extended some crucial drives. On offense the Rams generated 356 yards (196 passing), 5.5 yards per play and 22 first downs but also had a pretty rough success rate on third-down tries (3-of-10). LA had given up just 28 combined points over the previous two games before surrendering 33 to Philadelphia. The offense has a combined 59 points over the past two outings though, so it might be fun to try the over in this one.

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