Lions vs Browns Prediction 9/28/25 NFL Picks Today

In this article we will formulate a Lions vs Browns prediction for this NFL game on Sunday, September 28th at Ford Field in Detroit, Michigan. Let’s take a look at the prediction for this week 4 matchup.

Detroit Lions Betting Preview

The Detroit Lions are 2-1 this season after they defeated Baltimore by a score of 38-30 in their last game. Detroit was tied at 14 at the half and tied at 21 headed into the fourth, but they scored 17 points in the final quarter for the victory. The Lions out gained Baltimore by a total of 426-318, went 7-14 on third downs, and won the turnover battle by a total of 1-0 in the game. Jared Goff went 20-28 for 202 yards and one touchdown, while David Montgomery rushed 12 times for 151 yards and two scores. Amon-Ra St. Brown led the receivers with seven catches for 77 yards and one touchdown in the win. The Detroit defense recorded seven sacks and six tackles for loss in the victory. 

Detroit started the season with a 27-13 loss to Green Bay, but they did win their second game by a score of 52-21 against Chicago. The Lions are averaging 34.3 points per game with 245.3 passing yards and 149.0 rushing yards per game, while they are allowing 26.0 points against per game this season. Jared Goff has completed 77.9% of his passes for 761 yards, seven touchdowns, and one interception, while Amon-Ra St. Brown has caught 20 passes for 237 yards and four scores. David Montgomery has led the rushing attack with 233 yards and three touchdowns on 34 carries this season. 

Cleveland Browns Betting Preview

The Cleveland Browns are 1-2 this year after they defeated Green Bay by a score of 13-10 last time out. Cleveland trailed 10-0 in the fourth quarter, but they blocked a potential winning field goal and managed to kick their own field goal at the end of regulation for the win. The Browns were out gained by a total of 230-221, went 4-13 on third downs, and tied the turnover battle at one in the game. Joe Flacco went 21-36 for 142 yards and one interception, while Quinshon Judkins carried the ball 18 times for 94 yards and one score. David Njoku led the Cleveland receivers with five catches for 40 yards in the game. The Cleveland defense recorded five sacks and six tackles for loss in the victory. 

Cleveland started the season with a 17-16 loss to Cincinnati and a 41-17 loss to Baltimore in their first two games. The Browns are averaging 15.3 points per game with 203.7 passing yards and 86.7 rushing yards per game, while they are allowing 22.7 points against per game this season. Joe Flacco has completed 61.1% of his passes for 631 yards, two touchdowns, and four interceptions, while Harold Fannin Jr has caught 15 passes for 136 yards. Quinshon Judkins has led the rushing attack with 155 yards and one touchdown on 28 carries this year. 

Why the Lions will beat the Browns

Why the Browns will beat the Lions

Total Points Facts

Detroit Lions Player Prop Facts

Cleveland Browns Player Prop Facts

Matchup/League Facts

Lions vs Browns Prediction 

Detroit rolls into this matchup after dismantling Baltimore last week and they have plenty of momentum coming into this game. The Lions have looked very strong offensively in their last two games, but this Cleveland defense is still very good. The Browns are not a good offensive team, but they have not allowed many yards to the Packers or Ravens in their last two games. On the other side, the Detroit defense has been great in their last two games and their d-line really showed up last week. Take the under here. 

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