MNF: Arizona Cardinals vs San Francisco 49ers 11/21/22 NFL Picks, Predictions, Odds

The Arizona Cardinals and San Francisco 49ers do battle in week 11 Monday Night Football NFL action from Estadio Azteca. San Francisco is 5-4 on the season so far and fresh off a win versus the Chargers. As for Arizona, they’re 4-6 on the year. The Cardinals beat the Rams in their most recent game. Check back all season long for free NFL picks at Sports Chat Place.

San Francisco managed a 3-2 run over their first five games this year, taking wins over the Seahawks, Rams and Panthers. Since then the 49ers have gone 2-2 with losses to the Falcons and Chiefs before wins over the Rams and Chargers. 

In the Chargers game on Sunday, San Francisco faced an 18-10 deficit at the break. The 49ers went on a 12-0 run from there and took the game 22-16. QB Jimmy Garoppolo finished with 240 yards, and Elijah Mitchell led the rush on 89 yards from 18 carries. 

Over on the Arizona side, they were just 2-4 over their first six games, falling to the Chiefs, Rams, Eagles and Seahawks. The Cardinals have gone 2-2 in the four games since, beating the Saints and Rams with losses to the Vikings and Seahawks otherwise. 

In last Sunday’s matchup versus the Rams, Arizona jumped out to a 17-3 lead at halftime. The Cardinals scored 10 points in the fourth on the way to a 27-17 win. Colt McCoy put up 238 yards with one score, and James Conner rushed for 69 yards and two touchdowns. 

The 49ers are 5-0 ATS in their last five versus the NFC West and 15-4 in their last 19 Monday games. San Francisco is 9-2 ATS in their last 11 versus the NFC. 

Meanwhile, the Cardinals are 2-6 ATS versus a team with a winning record and 2-9 ATS in their last 11 Monday games. Arizona is 1-6 ATS in their last seven versus the NFC West. 

PICK: I’m going to take the Cardinals in this one. Arizona did a good enough job in their win over LA on Sunday, notching 298 total yards (78 rushing) and 18 first downs. The Cardinals avoided turnovers, but they also went just 5-of-15 on third-down tries and had 10 penalties. Arizona has plenty to clean up if they want to stay close in this one. 

As for San Francisco, they kept drives alive well in their win over the Chargers with a 9-of-17 run on third downs, just one turnover and five penalties. The 49ers have scored pretty well lately with 22 points or more in each of the last three games. Still, I think Arizona can stay within range and cover here, even if the Niners win.