The Arizona Cardinals and the New Orleans Saints meet in week 1 NFL action from Caesars Superdome on Sunday. We will look at this from a betting perspective and determine the best bets for this game. Here’s a Arizona Cardinals vs. New Orleans Saints prediction.
Arizona Cardinals Team Preview
The Arizona Cardinals enter 2025 following an 8-9 finish in 2024 that extended their playoff drought to three seasons under head coach Jonathan Gannon. Determined to upgrade the roster, the Cardinals added several veteran pieces on defense, signing linemen Calais Campbell and Dalvin Tomlinson along with pass rusher Josh Sweat to strengthen the front. On offense, they dealt wide receiver Rondale Moore to Atlanta in exchange for quarterback Desmond Ridder, adding insurance behind Kyler Murray. The draft brought a potential cornerstone in Ole Miss defensive tackle Walter Nolen, selected 16th overall, while Michigan cornerback Will Johnson was taken in the second round as a value pick after sliding due to injury concerns. The coaching staff remains unchanged, with Gannon and his coordinators returning to provide continuity on both sides of the ball. With impact veterans, young defensive talent, and a stable coaching group, the Cardinals look to move past last year’s struggles and reassert themselves in the NFC West.
Why the Arizona Cardinals will win
- The Saints have lost 10 of their last 11 Week 1 home games against NFC West opponents.
- The favorites have won each of the Saints’ last six games.
- The Cardinals have covered the spread in each of their last seven road games in September.
- The Saints have failed to cover the spread in each of their last four games as underdogs against NFC West opponents.
Arizona Cardinals Player Prop Facts
- Kyler Murray has recorded 23+ completions in six of the Cardinals’ last seven games.
- James Conner has recorded 73+ rushing yards in each of the Cardinals’ last four games against NFC South opponents.
- Kyler Murray has recorded 242+ passing yards in five of the Cardinals’ last six games against NFC opponents.
- Trey McBride has recorded 65+ receiving yards in seven of the Cardinals’ last eight games.
- James Conner has recorded 113+ rushing and receiving yards in six of his last seven appearances with the Cardinals as favorites.
- James Conner has scored at least one touchdown in each of his four previous appearances with his team as a favorite against NFC South opponents.
- Kyler Murray was the only player in the NFL to record 500 rushing yards with less than 100 attempts last season.
New Orleans Saints Team Preview
The New Orleans Saints will be out to right the ship in 2025, coming off a 5-12 season that extended their playoff drought to four years and ushered in a new era. Dennis Allen was dismissed after a 2-7 start, and the team turned to former Eagles offensive coordinator Kellen Moore as head coach, with Brandon Staley hired as defensive coordinator. The offseason brought notable roster changes, highlighted by the additions of wide receiver Brandin Cooks and defensive end Chase Young, while longtime contributors Michael Thomas, Marcus Maye, and Andrus Peat departed. In the draft, New Orleans used the ninth overall pick on Texas offensive tackle Kelvin Banks Jr. to solidify the line and added Louisville quarterback Tyler Shough in the second round as a developmental option alongside Spencer Rattler and Jake Haener. With a new coaching staff and a retooled roster blending veteran acquisitions and young talent, the Saints aim to reset their trajectory entering 2025.
Why the New Orleans Saints will win
- The Cardinals have lost each of their last four games as road favorites.
- The Saints have won each of their last six season openers.
- The underdogs have covered the spread in eight of the Cardinals’ last nine Week 1 games.
- The Cardinals have failed to cover the spread in each of their last four games as road favorites.
New Orleans Saints Player Prop Facts
- Alvin Kamara has scored the first touchdown in three of his last four September appearances with the Saints as underdogs.
- Alvin Kamara has scored at least one touchdown in each of his last four September appearances with the Saints as underdogs.
- Alvin Kamara has recorded 69+ rushing yards in each of his last six September appearances with the Saints as underdogs.
- Taysom Hill has recorded 39+ rushing and receiving yards in each of his last six Sunday appearances with the Saints as home underdogs.
- Brandin Cooks has recorded 44+ receiving yards in nine of his last 10 appearances with his team as a home underdog against NFC opponents.
- Alvin Kamara recorded the equal-most rushing touchdowns in a single game last season (3 vs Cowboys, Week 2).
Total Points Facts
- Eight of the Cardinals’ last nine road games in September have gone UNDER the total points line.
- Seven of the Saints’ last eight season openers against NFC opponents have gone OVER the total points line.
- Three of the last four Sunday games at Caesars Superdome have gone UNDER the total points line.
Arizona Cardinals vs. New Orleans Saints Prediction
I’m looking at the Cardinals here. It’s not easy laying points with teams on the road in week one, and historically, the Superdome has been a tough place to go on the road and compete let alone win, but I just don’t have any faith in the quarterback room for New Orleans as Rattler, Shough and Haener inspire little confidence, whether it’s as a whole or individually. I think Arizona’s just in a better place and I think they get it done here. Give me the Cardinals.