Rams vs 49ers Prediction 10/2/25 NFL Picks Today

In this article we will formulate a Rams vs 49ers prediction for this NFL game on Thursday, October 2nd at SoFi Stadium in Inglewood, California. Let’s take a look at the prediction for this week 5 matchup.

Los Angeles Rams Betting Preview

The Los Angeles Rams are 3-1 this season after they defeated Indianapolis by a score of 27-20 last week. Los Angeles led 13-10 at halftime, but they trailed 20-13 in the fourth quarter, before scoring 14 points in the final 3:20 to steal the win. The Rams out gained Indianapolis by a total of 462-333, went 4-12 on third downs, and won the turnover battle by a margin of 3-1 in the game. Matthew Stafford went 29-41 with 375 yards and three touchdowns, while Kyren Williams rushed 13 times for 77 yards. Puka Nacua led the LA receivers with 13 receptions for 170 yards and one score in the win. The Rams defense recorded two sacks and four tackles for loss in the game. 

In their first three games, Los Angeles defeated Houston and Tennessee to start the season, but they lost to Philadelphia in their third game. The Rams are averaging 25.0 points per game with 267.5 passing yards and 120.8 rushing yards per game, while they are allowing 20.3 points against per game this season. Matthew Stafford has completed 67.6% of his passes for 1,114 yards, eight touchdowns, and two interceptions, while Puka Nacua has 42 receptions for 503 yards and one touchdown. Kyren Williams has led the LA rushing attack with 303 yards and one score on 68 carries this season. 

San Francisco 49ers Betting Preview

The San Francisco 49ers are 3-1 this year after they lost to Jacksonville by a score of 26-21 last week. San Francisco trailed 17-6 at halftime and they cut the deficit to 17-14 in the third, but allowed the next nine points for the loss. The 49ers out gained Jacksonville by a total of 389-325, went 8-13 on third downs, and lost the turnover battle by a margin of 4-0 in the game. Brock Purdy went 22-38 for 309 yards, two touchdowns, and two interceptions, while Christian McCaffrey rushed 17 times for 49 yards. McCaffrey also led the receivers with six catches for 92 yards and one score in the loss. The SF defense recorded zero sacks and six tackles for loss in the game. 

In their first three games, San Francisco defeated Seattle by a score of 17-13, New Orleans by a score of 26-21, and Arizona by a score of 16-15. The 49ers are averaging 20.0 points per game with 280.0 passing yards and 88.0 rushing yards per game, while they are allowing 18.8 points against per game this season. Brock Purdy has completed 65.8% of his passes for 586 yards, four touchdowns, and four interceptions, while Ricky Pearsall has caught 20 passes for 327 yards. Christian McCaffrey has led the ground game with 69 carries for 225 yards this year. 

Why the 49ers will beat the Rams

Total Points Facts

Los Angeles Rams Player Prop Facts

San Francisco 49ers Player Prop Facts

Matchup/League Facts

Rams vs 49ers Prediction 

Both of these teams come into this matchup tied for first in the NFC West with the Seahawks, so this is a huge game in the division. The Rams lost in heartbreaking fashion against the Eagles two weeks ago, but managed to steal one against the Colts last week. San Francisco has played in four very close games to start the season, but turnovers got the best of them last week. This should be another classic Thursday Night Football game and even with a bunch of injuries, I like the 49ers with the points here. 

David Racey is 15-3 (83%) in the NFL over the last two weeks and he has been red hot this season. Click here for his premium plays for this week!

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