Saints vs 49ers Prediction 9/14/25 NFL Picks Today

The San Francisco 49ers and New Orleans Saints meet Sunday in NFL action at Caesars Superdome. Here’s a Saints vs 49ers Prediction. This article will include a Saints vs 49ers Pick.

San Francisco 49ers Betting Preview

The San Francisco 49ers beat the Seahawks, and play the Cardinals and Jaguars next. The San Francisco 49ers have lost 7 of their last 9 games. Brock Purdy is completing 74.3 percent of his passes for 277 yards, 2 touchdowns, and 2 interceptions. Ricky Pearsall and Christian McCaffrey have combined for 181 receiving yards on 13 catches, while Kyle Juszczyk has 2 receptions.


The San Francisco 49ers ground game is averaging 119 yards per contest, and Christian McCaffrey leads the way with 69 yards on 22 carries. Defensively, San Francisco is allowing 13 points and 230 yards per game. Fred Warner leads the San Francisco 49ers with 8 tackles, Nick Bosa has 1 sack and Upton Stout has 1 pass deflection.

New Orleans Saints Betting Preview

The New Orleans Saints lost to the Cardinals, and they play the Seahawks and Bills next. The New Orleans Saints have lost 5 straight games. Spencer Rattler is completing 58.7 percent of his passes for 214 yards, 0 touchdowns, and 0 interceptions. Juwan Johnson and Chris Olave have combined for 130 receiving yards on 15 catches, while Rashid Shaheed has 6 receptions.

The New Orleans Saints ground game is averaging 107 yards per contest, and Alvin Kamara leads the way with 45 yards and 1 touchdown. Defensively, New Orleans is allowing 20 points and 276 yards per game. Pete Werner leads the New Orleans Saints with 9 tackles, Cameron Jordan has 1.5 sacks and Carl Granderson has 2 pass deflections.

San Francisco 49ers @ New Orleans Saints Betting Trends: Week 2

Why the New Orleans Saints will win

Why the San Francisco 49ers will win

Total Points Facts

New Orleans Saints Player Prop Facts

San Francisco 49ers Player Prop Facts

Matchup/League Facts

Saints vs 49ers Prediction

The 49ers are the better team, as many expected the Saints to be the worst team in the league. However, the 49ers are starting the season with back-to-back road games, and a win over the Seahawks doesn’t make us forget the questions with this team and how last year played out. McCaffrey is still gimpy and George Kittle is now on the IR.

The 49ers are 6-10 ATS in their last 16 games when favorites of 3 or more points, and 7 of those failed covers were outright losses. The Saints put up a fight against the Cardinals opening week, and they have a major edge with not having to travel. The 49ers have depth issues on defense and injury concerns on offense to just throw these numbers out on the road. I’ll grab the points with the Saints at home.

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