49ers vs Panthers Prediction 11/24/25 NFL Picks Today

The Carolina Panthers and the San Francisco 49ers meet in week 12 NFL action from Levi’s Stadium on Monday. We will look at this from a betting perspective and determine the best bets for this game. Here’s a 49ers vs Panthers Prediction.

Carolina Panthers Recap

The Carolina Panthers come into this game looking to add on to a 30-27 win over Atlanta last time out to sit at 6-5 this season. After this game, Carolina will head home for a game against the Los Angeles Rams.


Panthers Alternate Wins & Losses In 5 Straight

Bryce Young has thrown for 1,962 yards, 14 touchdowns and 7 interceptions on 62.7% passing while Andy Dalton has 293 passing yards, a touchdown and an interception on 67.6% passing. Rico Dowdle has a team-high 833 rushing yards and 5 TDs and Chuba Hubbard has 334 rushing yards as well this season. Tetairoa McMillan has a team-high 54 catches for 746 yards and Xavier Legette has 264 receiving yards and 3 TDs while seven more Panthers have 100+ receiving yards as well on the year. On defense, Christian Rozeboom has a team-high 91 total tackles. As a unit, Carolina’s defense has combined for 16 sacks and 7 interceptions so far this season.

Why the Carolina Panthers will win

Carolina Panthers Player Prop Facts

San Francisco 49ers Recap

The San Francisco 49ers come into this game looking to add on to their 41-22 win over Arizona last time out to sit at 7-4 this season. After this game, San Francisco will head on the road for a game against the Cleveland Browns.

49ers Alternate Wins & Losses In 9 In A Row

Mac Jones has thrown for 2,151 yards, 13 touchdowns and 6 interceptions on 69.6% passing while Brock Purdy has thrown for 786 yards, 7 touchdowns and 4 interceptions on 67.7% passing. Christian McCaffrey has a team-high 707 rushing yards while also leading the 49ers in receiving with 74 grabs for 732 yards and 5 touchdowns. Ricky Pearsall has 327 receiving yards and 20 receptions while Kendrick Bourne has 482 receiving yards and Jauan Jennings has 378 receiving yards and 3 TDs. Two more 49ers have 200+ receiving yards and another pair have 150+ receiving yards as well on the year. On defense, Dee Winters has a team-high 77 total tackles. As a unit, San Francisco’s defense has combined for 12 sacks and 3 interceptions so far this season. 

Why the San Francisco 49ers will win

San Francisco 49ers Player Prop Facts

Total Points Facts

49ers vs Panthers Prediction

I’m on the over here. I think that San Francisco is going to be able to put up points here, but there’s also an avenue for success for Carolina, as San Francisco’s defense is just ravaged by injuries. We just saw Bryce Young set a franchise record for passing for Carolina, and this Panthers team is getting more and more confident in themselves with each passing week as the potential for playoff football draws near. Give me the over here.

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